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(Bio-)Hybrid Nanoparticles & Nanostructures BH2N

(Bio-)Hybrid Nanoparticles & Nanostructures (BH2N) is a group of the Nanosciences department from the laboratory ICB. It is lead by Nadine Millot and includes different activities.

Nadine MILLOT

Group head

nadine.millot[at]u-bourgogne.fr
Tél : +333 80 39 59 37

  • SPIONs-phtalocyanine (Pc) nanohybrids developed as bimodal contrast agents for optical imaging (OI) and magnetic resonance imaging (MRI)
  • SPIONs Nanohybrids surface modification by 3,4-dihydroxy-L-phenylalanine (LDOPA) or 3,4-dihydroxyhydrocinnamic acid (DHCA)
  • SPIONs-LDOPA-PEG2000-MANOTA[64Cu] Nanohybrids evaluated in vitro and in vivo by MRI-PET
  • Protein grafting at the surface of bimodal SPIONs to target cardiovascular diseases and monitor them by MRI-PET (cardiotoxicity induced by chemotherapy)
  • Combination of TiONts + AuNPs to optimize the nanoplatform dedicated to the radiosensibilization of prostate cancer
  • Neurodegenerative diseases: peroxisomal and mitochondrial targeting with multifunctional SPIONs

Related information: Chem. Commun. 2011, Chem. Commun. 2013, RSC. Adv. 2015, J. Biomed. Nanotechnol. 2015, EQUIPEX IMAPPI

Contacts: L. Maurizi, J. Boudon, N. Millot

  • TiONts-SPIONs: MRI-detectable nanocarriers
  • TiONts-phthalocyanine (Pc): promising optical imaging (OI)-detectable nanocarriers
  • TiONts-docetaxel (DTX): concentration of a radiosensitzing nanocarrier into tumors
  • TiONts-DOTA: nanohybrids biodistribution by SPECT-CT nuclear imaging

Related information: J. Phys. Chem. C 2011, RSC. Adv. 2015, Nanomedicine Ed. One Central Press 2014, Radiother. Oncol. 2013, Eur. J. Cancer 2014

Contacts: J. Boudon, N. Millot

  • Controlled synthesis, reproducible and 99% pure
  • TiONrs functionalization by polyethylene glycol (PEG) to graft proteins
  • Lysine coupling: cellular adhesion

Related information: Dalton Trans. 2015, Brevet 2014 WO 2014/079890

Contacts: V. Bérard, N. Millot

  • High yield synthesis of dispersed MSNs
  • Improvement of the structural stability of MSNs
  • Study of the influence of surface chemistry on the dispersion of MSNs and the encapsulation of drugs
  • Study of the influence of surface chemistry on MSNs cytotoxicity (preliminary data)
  • Development of MSNs-gold nanoparticles (AuNPs) nanohybrids or (AuNPs) for pH-sensitive drug delivery (by pH-cleavable bonds)
  • in vitro and in vivo evaluation of the best formulations of MSNs

Related information: J. Non-Cryst. Solids 2015, J. Nanopart. Res. 2015

Contact: F. Bouyer

  • Random LASERs
  • Understanding of the catalyzed growth of doped TiO2 nanostructures

Related information: Optics Express 2012

Contact: D. Chaumont

  • Development of novel tantalum oxide nanoparticles (TaONPs) as a theranostic platform
  • Functionalization of TaONPs surface for the grafting of molecules of interest
  • Grafting of anticancer molecules
  • Tomodensitometry

Contacts: J. Boudon, N. Millot

  • Cytotoxicity assays (MTT, Alamar blue, kinetics of RNA synthesis)
  • Genotoxicity assays (comet assay, Ames assay, micronucleus assays)
  • Carcinogenicity assays (cell transformation assay)
  • Study, understanding and control of nanomaterial-protein interactions

Related information: Nanotoxicology 2013, plateforme “NanoCare Bourgogne", Nanoscale 2014, Biomaterials Science 2015

Contacts: L. Maurizi, N. Millot

  • role of size, shape, crystalline structure and environment
  • continuum elasticity, symmetry of the vibrations
  • Raman scattering, light-vibration coupling

Related information: Phys. Rev. B 2018

Contact: L. Saviot

Means & applications

The group has different elaboration and characterization techniques dedicated to the engineered nanoparticles and nanostructures.

Elaboration

Characterization

Applications

  • Medical imaging: magnetic (MRI), nuclear (SPECT, PET)
  • Therapy: anticancer nanodrugs, tumor radiosensibilization, photodynamic therapy
  • Energy (solar cells, lithium batteries…), environment

Team members

  • Annette Luce, PhD student
  • Mohamad Abd Alaziz Alzaibak, graduate student, Master LipTherapI, UBFC
  • Dihia Refsi, graduate student, Master Recherche Drug Design, Univ. Caen Normandie
  • Lucas Denis, graduate student, Master CDM, UBFC
  • Daniel Raheem, undergraduate student, IT Carlow, Ireland

BH2N team welcomes
Dr. Mitsunori YADA (Saga University, Japan)
Department of Chemistry and Applied Chemistry
from May 27 to August 26 2019
Details: Dpt. Chem. Univ. Saga’s website
 
BH2N team has welcome
Prof. Dr. Gerold Schneider(Technische Universität Hamburg, Germany)
Head of Institute of Advanced Ceramics
From June 18th to July 13th 2018
Details:
Institute Advanced Ceramics’ website
 

BH2N team has welcome
Dr. Katrin Löschner(Technical University of Denmark, Denmark)

National Food Institute

Research Group for Nano-Bio Science
From 3rd to May 29th 2018
More details:

K. Löschner’s webpage

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