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(Bio-)Hybrid Nanoparticles & Nanostructures

(Bio-)Hybrid Nanoparticles & Nanostructures (BH2N) is a group of the Nanosciences department from the laboratory ICB. It is lead by Julien Boudon and includes different activities.

Julien BOUDON

Group head

julien.boudon[at]u-bourgogne.fr
Tél : +333 80 39 59 42

  • SPIONs-phtalocyanine (Pc) nanohybrids developed as bimodal contrast agents for optical imaging (OI) and magnetic resonance imaging (MRI)
  • SPIONs Nanohybrids surface modification by 3,4-dihydroxy-L-phenylalanine (LDOPA) or 3,4-dihydroxyhydrocinnamic acid (DHCA)
  • SPIONs-LDOPA-PEG2000-MANOTA[64Cu] Nanohybrids evaluated in vitro and in vivo by MRI-PET
  • Protein grafting at the surface of bimodal SPIONs to target cardiovascular diseases and monitor them by MRI-PET (cardiotoxicity induced by chemotherapy)
  • Combination of TiONts + AuNPs to optimize the nanoplatform dedicated to the radiosensibilization of prostate cancer
  • Neurodegenerative diseases: peroxisomal and mitochondrial targeting with multifunctional SPIONs

Related information: Chem. Commun. 2011, Chem. Commun. 2013, RSC. Adv. 2015, J. Biomed. Nanotechnol. 2015, EQUIPEX IMAPPI

Contacts: L. Maurizi, J. Boudon, N. Millot

  • TiONts-SPIONs: MRI-detectable nanocarriers
  • TiONts-phthalocyanine (Pc): promising optical imaging (OI)-detectable nanocarriers
  • TiONts-docetaxel (DTX): concentration of a radiosensitzing nanocarrier into tumors
  • TiONts-DOTA: nanohybrids biodistribution by SPECT-CT nuclear imaging

Related information: J. Phys. Chem. C 2011, RSC. Adv. 2015, Nanomedicine Ed. One Central Press 2014, Radiother. Oncol. 2013, Eur. J. Cancer 2014

Contacts: J. Boudon, N. Millot

  • Controlled synthesis, reproducible and 99% pure
  • TiONrs functionalization by polyethylene glycol (PEG) to graft proteins
  • Lysine coupling: cellular adhesion

Related information: Dalton Trans. 2015, Brevet 2014 WO 2014/079890

Contacts: V. Bérard, N. Millot

  • role of size, shape, crystalline structure and environment
  • continuum elasticity, symmetry of the vibrations
  • Raman scattering, light-vibration coupling

Related information: Phys. Rev. B 2018, ACS Nano 2020

Contact: L. Saviot

  • Development of novel tantalum oxide nanoparticles (TaONPs) as a theranostic platform
  • Functionalization of TaONPs surface for the grafting of molecules of interest
  • Grafting of anticancer molecules
  • Tomodensitometry

Contacts: J. Boudon, N. Millot

  • Cytotoxicity assays (MTT, Alamar blue, kinetics of RNA synthesis)
  • Genotoxicity assays (comet assay, Ames assay, micronucleus assays)
  • Carcinogenicity assays (cell transformation assay)
  • Study, understanding and control of nanomaterial-protein interactions

Related information: Nanotoxicology 2013, plateforme “NanoCare Bourgogne", Nanoscale 2014, Biomaterials Science 2015

Contacts: L. Maurizi, N. Millot

Means & applications

The group has different elaboration and characterization techniques dedicated to the engineered nanoparticles and nanostructures.

Elaboration

Characterization

Applications

  • Medical imaging: magnetic (MRI), nuclear (SPECT, PET)
  • Therapy: anticancer nanodrugs, tumor radiosensibilization, photodynamic therapy

Team members

Associated collaborators

  • Nicole ABOU HAMAD, PhD student (Agrosup)
  • Laroussi CHAABANE, Postdoctoral fellow (Agrosup)
  • Damien GOULLEY, PhD student (Pharma)
  • Alan ZERROUKI, PhD student (Interface/PMDM)

BH2N team has welcome
Dr. Mitsunori YADA (Saga University, Japan)
Department of Chemistry and Applied Chemistry
from May 27 to August 26 2019
Details: Dpt. Chem. Univ. Saga’s website

BH2N team has welcome
Prof. Dr. Gerold Schneider(Technische Universität Hamburg, Germany)
Head of Institute of Advanced Ceramics
From June 18th to July 13th 2018
Details:
Institute Advanced Ceramics’ website

BH2N team has welcome
Dr. Katrin Löschner(Technical University of Denmark, Denmark)National Food InstituteResearch Group for Nano-Bio Science
From 3rd to May 29th 2018
More details:K. Löschner’s webpage
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(Bio-)Hybrid Nanoparticles & Nanostructures

(Bio-)Hybrid Nanoparticles & Nanostructures (BH2N) is a group of the Nanosciences department from the laboratory ICB. It is lead by Julien Boudon and includes different activities.
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Julien BOUDON

Group head

julien.boudon[at]u-bourgogne.fr
Tél : +333 80 39 59 42

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PhD offer
Starting early October 2020
Are you Interested in starting a PhD on the "Synthesis of hybrid nanoparticles targeting extracellular vesicles"? Apply the offer by clicking the image on the left (pdf file, 221 Ko).
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{slide=Iron Oxide Nanoparticles (SPIONs) for multimodal imaging}

  • SPIONs-phtalocyanine (Pc) nanohybrids developed as bimodal contrast agents for optical imaging (OI) and magnetic resonance imaging (MRI)
  • SPIONs Nanohybrids surface modification by 3,4-dihydroxy-L-phenylalanine (LDOPA) or 3,4-dihydroxyhydrocinnamic acid (DHCA)
  • SPIONs-LDOPA-PEG2000-MANOTA[64Cu] Nanohybrids evaluated in vitro and in vivo by MRI-PET
  • Protein grafting at the surface of bimodal SPIONs to target cardiovascular diseases and monitor them by MRI-PET (cardiotoxicity induced by chemotherapy)
  • Combination of TiONts + AuNPs to optimize the nanoplatform dedicated to the radiosensibilization of prostate cancer
  • Neurodegenerative diseases: peroxisomal and mitochondrial targeting with multifunctional SPIONs

Related information: Chem. Commun. 2011, Chem. Commun. 2013, RSC. Adv. 2015, J. Biomed. Nanotechnol. 2015, EQUIPEX IMAPPI

Contacts: L. Maurizi, J. Boudon, N. Millot

{/slide}

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{slide=Therapeutic nanocarriers made from titanate nanotubes}

  • TiONts-SPIONs: MRI-detectable nanocarriers
  • TiONts-phthalocyanine (Pc): promising optical imaging (OI)-detectable nanocarriers
  • TiONts-docetaxel (DTX): concentration of a radiosensitzing nanocarrier into tumors
  • TiONts-DOTA: nanohybrids biodistribution by SPECT-CT nuclear imaging

Related information: J. Phys. Chem. C 2011, RSC. Adv. 2015, Nanomedicine Ed. One Central Press 2014, Radiother. Oncol. 2013, Eur. J. Cancer 2014

Contacts: J. Boudon, N. Millot

{/slide}

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{slide=Titanate nanoribbons (TiONrs) for regenerative medicine}

  • Controlled synthesis, reproducible and 99% pure
  • TiONrs functionalization by polyethylene glycol (PEG) to graft proteins
  • Lysine coupling: cellular adhesion

Related information: Dalton Trans. 2015, Brevet 2014 WO 2014/079890

Contacts: V. Bérard, N. Millot

{/slide}

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{slide=Elaboration of mesoporous silica nanoparticles (MSNs) for a controlled delivery of anticancer drugs}

  • High yield synthesis of dispersed MSNs
  • Improvement of the structural stability of MSNs
  • Study of the influence of surface chemistry on the dispersion of MSNs and the encapsulation of drugs
  • Study of the influence of surface chemistry on MSNs cytotoxicity (preliminary data)
  • Development of MSNs-gold nanoparticles (AuNPs) nanohybrids or (AuNPs) for pH-sensitive drug delivery (by pH-cleavable bonds)
  • in vitro and in vivo evaluation of the best formulations of MSNs

Related information: J. Non-Cryst. Solids 2015, J. Nanopart. Res. 2015

Contact: F. Bouyer

{/slide}

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{slide=Titanate nanoribbons (TiONrs) for regenerative medicine}

  • Controlled synthesis, reproducible and 99% pure
  • TiONrs functionalization by polyethylene glycol (PEG) to graft proteins
  • Lysine coupling: cellular adhesion

Related information: Dalton Trans. 2015, Brevet 2014 WO 2014/079890

Contacts: V. Bérard, N. Millot

{/slide}

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{slide=Acoustic vibrations of nano-objects}

  • role of size, shape, crystalline structure and environment
  • continuum elasticity, symmetry of the vibrations
  • Raman scattering, light-vibration coupling

Related information: Phys. Rev. B 2018, ACS Nano 2020

Contact: L. Saviot

{/slide}

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{slide=Tantalum oxide nanoparticles (TaONPs)}

  • Development of novel tantalum oxide nanoparticles (TaONPs) as a theranostic platform
  • Functionalization of TaONPs surface for the grafting of molecules of interest
  • Grafting of anticancer molecules
  • Tomodensitometry

Contacts: J. Boudon, N. Millot

{/slide}

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{slide=Nanoparticle toxicity and security evaluation}

  • Cytotoxicity assays (MTT, Alamar blue, kinetics of RNA synthesis)
  • Genotoxicity assays (comet assay, Ames assay, micronucleus assays)
  • Carcinogenicity assays (cell transformation assay)
  • Study, understanding and control of nanomaterial-protein interactions

Related information: Nanotoxicology 2013, plateforme "NanoCare Bourgogne", Nanoscale 2014, Biomaterials Science 2015

Contacts: L. Maurizi, N. Millot

{/slide}

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{slide=TiO2 growth by MOCVD and study of growth mechanisms}

  • Random LASERs
  • Understanding of the catalyzed growth of doped TiO2 nanostructures

Related information: Optics Express 2012

Contact: D. Chaumont

{/slide}

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{slide=Tantalum oxide nanoparticles (TaONPs)}

  • Development of novel tantalum oxide nanoparticles (TaONPs) as a theranostic platform
  • Functionalization of TaONPs surface for the grafting of molecules of interest
  • Grafting of anticancer molecules
  • Tomodensitometry

Contacts: J. Boudon, N. Millot

{/slide}

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{slide=BH2N publications}

[iframe src="/publications/groupes/NANO1.html"width="100%" height="500"]

{/slide}

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{slide=BH2N publications}

[iframe src="/publications/groupes/NANO1.html"width="100%" height="500"]

{/slide}

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Means & applications

The group has different elaboration and characterization techniques dedicated to the engineered nanoparticles and nanostructures.

[/kc_column_text][kc_spacing height="20" _id="370552"][kc_column_text _id="702090"]

Elaboration

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Characterization

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Applications

[/kc_column_text][kc_column_text _id="719495"]
  • Medical imaging: magnetic (MRI), nuclear (SPECT, PET)
  • Therapy: anticancer nanodrugs, tumor radiosensibilization, photodynamic therapy
[/kc_column_text][/kc_column][kc_column width="10%" _id="653762"][/kc_column][kc_column width="34%" _id="887455"][kc_column_text _id="77119"]

Team members

[/kc_column_text][kc_spacing height="20" _id="72649"][kc_column_text _id="96309"]

{slide=Permanent members}

{/slide}

[/kc_column_text][kc_spacing height="20" _id="34060"][kc_column_text _id="58525"]

{slide=Non-permanent members}

Associated collaborators

  • Nicole ABOU HAMAD, PhD student (Agrosup)
  • Laroussi CHAABANE, Postdoctoral fellow (Agrosup)
  • Damien GOULLEY, PhD student (Pharma)
  • Alan ZERROUKI, PhD student (Interface/PMDM)

{/slide}

[/kc_column_text][kc_spacing height="20" _id="679858"][kc_column_text _id="413894"]

{slide=Scientific guests}


BH2N team has welcome
Dr. Mitsunori YADA (Saga University, Japan)
Department of Chemistry and Applied Chemistry
from May 27 to August 26 2019
Details: Dpt. Chem. Univ. Saga's website

BH2N team has welcome
Prof. Dr. Gerold Schneider(Technische Universität Hamburg, Germany)
Head of Institute of Advanced Ceramics
From June 18th to July 13th 2018
Details:
Institute Advanced Ceramics' website

BH2N team has welcome
Dr. Katrin Löschner(Technical University of Denmark, Denmark)National Food InstituteResearch Group for Nano-Bio Science
From 3rd to May 29th 2018
More details:K. Löschner's webpage

{/slide}

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{slide=Former members}

{/slide}

[/kc_column_text][/kc_column][/kc_row]

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