(Bio-)Hybrid Nanoparticles & Nanostructures BH2N
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(Bio-)Hybrid Nanoparticles & Nanostructures (BH2N) is a group of the Nanosciences department from the laboratory ICB. It is lead by Nadine Millot and includes different activities. |
Nadine MILLOT
Group head
nadine.millot[at]u-bourgogne.fr
Tél : +333 80 39 59 37
- SPIONs-phtalocyanine (Pc) nanohybrids developed as bimodal contrast agents for optical imaging (OI) and magnetic resonance imaging (MRI)
- SPIONs Nanohybrids surface modification by 3,4-dihydroxy-L-phenylalanine (LDOPA) or 3,4-dihydroxyhydrocinnamic acid (DHCA)
- SPIONs-LDOPA-PEG2000-MANOTA[64Cu] Nanohybrids evaluated in vitro and in vivo by MRI-PET
- Protein grafting at the surface of bimodal SPIONs to target cardiovascular diseases and monitor them by MRI-PET (cardiotoxicity induced by chemotherapy)
- Combination of TiONts + AuNPs to optimize the nanoplatform dedicated to the radiosensibilization of prostate cancer
- Neurodegenerative diseases: peroxisomal and mitochondrial targeting with multifunctional SPIONs
Related information: Chem. Commun. 2011, Chem. Commun. 2013, RSC. Adv. 2015, J. Biomed. Nanotechnol. 2015, EQUIPEX IMAPPI
Contacts: L. Maurizi, J. Boudon, N. Millot
- TiONts-SPIONs: MRI-detectable nanocarriers
- TiONts-phthalocyanine (Pc): promising optical imaging (OI)-detectable nanocarriers
- TiONts-docetaxel (DTX): concentration of a radiosensitzing nanocarrier into tumors
- TiONts-DOTA: nanohybrids biodistribution by SPECT-CT nuclear imaging
Related information: J. Phys. Chem. C 2011, RSC. Adv. 2015, Nanomedicine Ed. One Central Press 2014, Radiother. Oncol. 2013, Eur. J. Cancer 2014
- Controlled synthesis, reproducible and 99% pure
- TiONrs functionalization by polyethylene glycol (PEG) to graft proteins
- Lysine coupling: cellular adhesion
Related information: Dalton Trans. 2015, Brevet 2014 WO 2014/079890
- High yield synthesis of dispersed MSNs
- Improvement of the structural stability of MSNs
- Study of the influence of surface chemistry on the dispersion of MSNs and the encapsulation of drugs
- Study of the influence of surface chemistry on MSNs cytotoxicity (preliminary data)
- Development of MSNs-gold nanoparticles (AuNPs) nanohybrids or (AuNPs) for pH-sensitive drug delivery (by pH-cleavable bonds)
- in vitro and in vivo evaluation of the best formulations of MSNs
Related information: J. Non-Cryst. Solids 2015, J. Nanopart. Res. 2015
Contact: F. Bouyer
- Cytotoxicity assays (MTT, Alamar blue, kinetics of RNA synthesis)
- Genotoxicity assays (comet assay, Ames assay, micronucleus assays)
- Carcinogenicity assays (cell transformation assay)
- Study, understanding and control of nanomaterial-protein interactions
Related information: Nanotoxicology 2013, plateforme “NanoCare Bourgogne", Nanoscale 2014, Biomaterials Science 2015
Contacts: L. Maurizi, N. Millot
Means & applications
The group has different elaboration and characterization techniques dedicated to the engineered nanoparticles and nanostructures.
Elaboration
Characterization
Applications
- Medical imaging: magnetic (MRI), nuclear (SPECT, PET)
- Therapy: anticancer nanodrugs, tumor radiosensibilization, photodynamic therapy
Team members
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BH2N team welcomes Dr. Mitsunori YADA (Saga University, Japan) Department of Chemistry and Applied Chemistry from May 27 to August 26 2019 Details: Dpt. Chem. Univ. Saga’s website |
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BH2N team has welcome Prof. Dr. Gerold Schneider(Technische Universität Hamburg, Germany) Head of Institute of Advanced Ceramics From June 18th to July 13th 2018 Details: Institute Advanced Ceramics’ website |
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BH2N team has welcome Dr. Katrin Löschner(Technical University of Denmark, Denmark)National Food InstituteResearch Group for Nano-Bio Science From 3rd to May 29th 2018 More details:K. Löschner’s webpage |
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