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(Bio-)Hybrid Nanoparticles & Nanostructures BH2N

(Bio-)Hybrid Nanoparticles & Nanostructures (BH2N) is a group of the Nanosciences department from the laboratory ICB. It is lead by Nadine Millot and includes different activities.

Nadine MILLOT

Group head

nadine.millot[at]u-bourgogne.fr
Tél : +333 80 39 59 37

  • SPIONs-phtalocyanine (Pc) nanohybrids developed as bimodal contrast agents for optical imaging (OI) and magnetic resonance imaging (MRI)
  • SPIONs Nanohybrids surface modification by 3,4-dihydroxy-L-phenylalanine (LDOPA) or 3,4-dihydroxyhydrocinnamic acid (DHCA)
  • SPIONs-LDOPA-PEG2000-MANOTA[64Cu] Nanohybrids evaluated in vitro and in vivo by MRI-PET
  • Protein grafting at the surface of bimodal SPIONs to target cardiovascular diseases and monitor them by MRI-PET (cardiotoxicity induced by chemotherapy)
  • Combination of TiONts + AuNPs to optimize the nanoplatform dedicated to the radiosensibilization of prostate cancer
  • Neurodegenerative diseases: peroxisomal and mitochondrial targeting with multifunctional SPIONs

Related information: Chem. Commun. 2011, Chem. Commun. 2013, RSC. Adv. 2015, J. Biomed. Nanotechnol. 2015, EQUIPEX IMAPPI

Contacts: L. Maurizi, J. Boudon, N. Millot

  • TiONts-SPIONs: MRI-detectable nanocarriers
  • TiONts-phthalocyanine (Pc): promising optical imaging (OI)-detectable nanocarriers
  • TiONts-docetaxel (DTX): concentration of a radiosensitzing nanocarrier into tumors
  • TiONts-DOTA: nanohybrids biodistribution by SPECT-CT nuclear imaging

Related information: J. Phys. Chem. C 2011, RSC. Adv. 2015, Nanomedicine Ed. One Central Press 2014, Radiother. Oncol. 2013, Eur. J. Cancer 2014

Contacts: J. Boudon, N. Millot

  • Controlled synthesis, reproducible and 99% pure
  • TiONrs functionalization by polyethylene glycol (PEG) to graft proteins
  • Lysine coupling: cellular adhesion

Related information: Dalton Trans. 2015, Brevet 2014 WO 2014/079890

Contacts: V. Bérard, N. Millot

  • High yield synthesis of dispersed MSNs
  • Improvement of the structural stability of MSNs
  • Study of the influence of surface chemistry on the dispersion of MSNs and the encapsulation of drugs
  • Study of the influence of surface chemistry on MSNs cytotoxicity (preliminary data)
  • Development of MSNs-gold nanoparticles (AuNPs) nanohybrids or (AuNPs) for pH-sensitive drug delivery (by pH-cleavable bonds)
  • in vitro and in vivo evaluation of the best formulations of MSNs

Related information: J. Non-Cryst. Solids 2015, J. Nanopart. Res. 2015

Contact: F. Bouyer

  • Random LASERs
  • Understanding of the catalyzed growth of doped TiO2 nanostructures

Related information: Optics Express 2012

Contact: D. Chaumont

  • Development of novel tantalum oxide nanoparticles (TaONPs) as a theranostic platform
  • Functionalization of TaONPs surface for the grafting of molecules of interest
  • Grafting of anticancer molecules
  • Tomodensitometry

Contacts: J. Boudon, N. Millot

  • Cytotoxicity assays (MTT, Alamar blue, kinetics of RNA synthesis)
  • Genotoxicity assays (comet assay, Ames assay, micronucleus assays)
  • Carcinogenicity assays (cell transformation assay)
  • Study, understanding and control of nanomaterial-protein interactions

Related information: Nanotoxicology 2013, plateforme “NanoCare Bourgogne", Nanoscale 2014, Biomaterials Science 2015

Contacts: L. Maurizi, N. Millot

  • role of size, shape, crystalline structure and environment
  • continuum elasticity, symmetry of the vibrations
  • Raman scattering, light-vibration coupling

Related information: Phys. Rev. B 2018

Contact: L. Saviot

Means & applications

The group has different elaboration and characterization techniques dedicated to the engineered nanoparticles and nanostructures.

Elaboration

Characterization

Applications

  • Medical imaging: magnetic (MRI), nuclear (SPECT, PET)
  • Therapy: anticancer nanodrugs, tumor radiosensibilization, photodynamic therapy
  • Energy (solar cells, lithium batteries…), environment

Team members


BH2N team welcomes
Dr. Mitsunori YADA (Saga University, Japan)
Department of Chemistry and Applied Chemistry
from May 27 to August 26 2019
Details: Dpt. Chem. Univ. Saga's website
 
BH2N team has welcome
Prof. Dr. Gerold Schneider(Technische Universität Hamburg, Germany)
Head of Institute of Advanced Ceramics
From June 18th to July 13th 2018
Details:
Institute Advanced Ceramics' website
 

BH2N team has welcome
Dr. Katrin Löschner(Technical University of Denmark, Denmark)

National Food Institute

Research Group for Nano-Bio Science
From 3rd to May 29th 2018
More details:

K. Löschner's webpage

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