(Bio-)Hybrid Nanoparticles & Nanostructures
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(Bio-)Hybrid Nanoparticles & Nanostructures (BH2N) is a group of the Nanosciences department from the laboratory ICB. It is lead by Julien Boudon and includes different activities. |
Julien BOUDON
Group head
julien.boudon[at]u-bourgogne.fr
Tél : +333 80 39 59 42
Means & applications
The group has different elaboration and characterization techniques dedicated to the engineered nanoparticles and nanostructures.
Elaboration
Characterization
Applications
- Medical imaging: magnetic (MRI), nuclear (SPECT, PET)
- Therapy: anticancer nanodrugs, tumor radiosensibilization, photodynamic therapy
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(Bio-)Hybrid Nanoparticles & Nanostructures
(Bio-)Hybrid Nanoparticles & Nanostructures (BH2N) is a group of the Nanosciences department from the laboratory ICB. It is lead by Julien Boudon and includes different activities. Julien BOUDON
Group head
julien.boudon[at]u-bourgogne.fr
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Tél : +333 80 39 59 42
{slide=Iron Oxide Nanoparticles (SPIONs) for multimodal imaging}
- SPIONs-phtalocyanine (Pc) nanohybrids developed as bimodal contrast agents for optical imaging (OI) and magnetic resonance imaging (MRI)
- SPIONs Nanohybrids surface modification by 3,4-dihydroxy-L-phenylalanine (LDOPA) or 3,4-dihydroxyhydrocinnamic acid (DHCA)
- SPIONs-LDOPA-PEG2000-MANOTA[64Cu] Nanohybrids evaluated in vitro and in vivo by MRI-PET
- Protein grafting at the surface of bimodal SPIONs to target cardiovascular diseases and monitor them by MRI-PET (cardiotoxicity induced by chemotherapy)
- Combination of TiONts + AuNPs to optimize the nanoplatform dedicated to the radiosensibilization of prostate cancer
- Neurodegenerative diseases: peroxisomal and mitochondrial targeting with multifunctional SPIONs
Related information: Chem. Commun. 2011, Chem. Commun. 2013, RSC. Adv. 2015, J. Biomed. Nanotechnol. 2015, EQUIPEX IMAPPI
Contacts: L. Maurizi, J. Boudon, N. Millot
{/slide}
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- TiONts-SPIONs: MRI-detectable nanocarriers
- TiONts-phthalocyanine (Pc): promising optical imaging (OI)-detectable nanocarriers
- TiONts-docetaxel (DTX): concentration of a radiosensitzing nanocarrier into tumors
- TiONts-DOTA: nanohybrids biodistribution by SPECT-CT nuclear imaging
Related information: J. Phys. Chem. C 2011, RSC. Adv. 2015, Nanomedicine Ed. One Central Press 2014, Radiother. Oncol. 2013, Eur. J. Cancer 2014
Contacts: J. Boudon, N. Millot
{/slide}
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- Controlled synthesis, reproducible and 99% pure
- TiONrs functionalization by polyethylene glycol (PEG) to graft proteins
- Lysine coupling: cellular adhesion
Related information: Dalton Trans. 2015, Brevet 2014 WO 2014/079890
Contacts: V. Bérard, N. Millot
{/slide}
[/kc_column_text][/kc_column][kc_column width="12%" _id="871355"][/kc_column][kc_column width="40%" _id="123983"][kc_single_image image_size="100x100" _id="974496" image_source="media_library" image="12022"][kc_column_text _id="724895"]{slide=Elaboration of mesoporous silica nanoparticles (MSNs) for a controlled delivery of anticancer drugs}
- High yield synthesis of dispersed MSNs
- Improvement of the structural stability of MSNs
- Study of the influence of surface chemistry on the dispersion of MSNs and the encapsulation of drugs
- Study of the influence of surface chemistry on MSNs cytotoxicity (preliminary data)
- Development of MSNs-gold nanoparticles (AuNPs) nanohybrids or (AuNPs) for pH-sensitive drug delivery (by pH-cleavable bonds)
- in vitro and in vivo evaluation of the best formulations of MSNs
Related information: J. Non-Cryst. Solids 2015, J. Nanopart. Res. 2015
Contact: F. Bouyer
{/slide}
[/kc_column_text][/kc_column][kc_column width="4%" _id="106071"][/kc_column][/kc_row][kc_row use_container="yes" _id="184955" cols_gap="{`kc-css`:{}}" force="__empty__" equal_height="yes" column_align="middle"][kc_column width="4%" _id="406236"][/kc_column][kc_column width="40%" _id="242194"][kc_single_image image_size="100x100" _id="378279" image_source="media_library" image="12027"][kc_column_text _id="852956"]{slide=Titanate nanoribbons (TiONrs) for regenerative medicine}
- Controlled synthesis, reproducible and 99% pure
- TiONrs functionalization by polyethylene glycol (PEG) to graft proteins
- Lysine coupling: cellular adhesion
Related information: Dalton Trans. 2015, Brevet 2014 WO 2014/079890
Contacts: V. Bérard, N. Millot
{/slide}
[/kc_column_text][/kc_column][kc_column width="12%" _id="357995"][/kc_column][kc_column width="40%" _id="693763"][kc_single_image image_size="full" _id="587684" image_source="media_library" image="12111"][kc_column_text _id="599586"]{slide=Acoustic vibrations of nano-objects}
- role of size, shape, crystalline structure and environment
- continuum elasticity, symmetry of the vibrations
- Raman scattering, light-vibration coupling
Related information: Phys. Rev. B 2018, ACS Nano 2020
Contact: L. Saviot
{/slide}
[/kc_column_text][/kc_column][kc_column width="4%" _id="521731"][/kc_column][/kc_row][kc_row use_container="yes" _id="505510"][kc_column width="12/12" video_mute="no" _id="811287"][kc_spacing height="30px" _id="761160"][/kc_column][/kc_row][kc_row use_container="yes" _id="871944" cols_gap="{`kc-css`:{}}" force="__empty__" container_class="full bg-rs" equal_height="yes" column_align="middle"][kc_column width="4%" _id="617367"][/kc_column][kc_column width="40%" _id="831389"][kc_spacing height="20" _id="292888"][kc_single_image image_size="100x100" _id="151884" image_source="media_library" image="12025"][kc_column_text _id="421292"]{slide=Tantalum oxide nanoparticles (TaONPs)}
- Development of novel tantalum oxide nanoparticles (TaONPs) as a theranostic platform
- Functionalization of TaONPs surface for the grafting of molecules of interest
- Grafting of anticancer molecules
- Tomodensitometry
Contacts: J. Boudon, N. Millot
{/slide}
[/kc_column_text][kc_spacing height="20" _id="24463"][/kc_column][kc_column width="12%" _id="368105"][/kc_column][kc_column width="40%" _id="150827"][kc_spacing height="20" _id="576586"][kc_single_image image_size="100x100" _id="339581" image_source="media_library" image="12023"][kc_column_text _id="788811"]{slide=Nanoparticle toxicity and security evaluation}
- Cytotoxicity assays (MTT, Alamar blue, kinetics of RNA synthesis)
- Genotoxicity assays (comet assay, Ames assay, micronucleus assays)
- Carcinogenicity assays (cell transformation assay)
- Study, understanding and control of nanomaterial-protein interactions
Related information: Nanotoxicology 2013, plateforme "NanoCare Bourgogne", Nanoscale 2014, Biomaterials Science 2015
Contacts: L. Maurizi, N. Millot
{/slide}
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- Random LASERs
- Understanding of the catalyzed growth of doped TiO2 nanostructures
Related information: Optics Express 2012
Contact: D. Chaumont
{/slide}
[/kc_column_text][kc_spacing height="20" _id="481169"][/kc_column][kc_column width="12%" _id="582570"][/kc_column][kc_column width="40%" _id="402681"][kc_spacing height="20" _id="919150"][kc_single_image image_size="100x100" _id="180655" image_source="media_library" image="12025"][kc_column_text _id="937173"]{slide=Tantalum oxide nanoparticles (TaONPs)}
- Development of novel tantalum oxide nanoparticles (TaONPs) as a theranostic platform
- Functionalization of TaONPs surface for the grafting of molecules of interest
- Grafting of anticancer molecules
- Tomodensitometry
Contacts: J. Boudon, N. Millot
{/slide}
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[iframe src="/publications/groupes/NANO1.html"width="100%" height="500"]
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The group has different elaboration and characterization techniques dedicated to the engineered nanoparticles and nanostructures.
[/kc_column_text][kc_spacing height="20" _id="370552"][kc_column_text _id="702090"]Elaboration
[/kc_column_text][kc_spacing height="20" _id="462698"][kc_carousel_images img_size="full" items_number="3" tablet="2" mobile="1" speed="100" pagination="__empty__" auto_play="__empty__" alt_text="yes" _id="468034" images="11865,11860,11861,11868" onclick="lightbox" navigation="yes" nav_style="arrow" auto_height="yes"][kc_spacing height="20" _id="906740"][kc_column_text _id="255827"]Characterization
[/kc_column_text][kc_spacing height="20" _id="902890"][kc_carousel_images img_size="full" items_number="3" tablet="2" mobile="1" speed="500" pagination="__empty__" auto_play="__empty__" alt_text="yes" _id="821704" images="11858,11857,11858,11872,11866,11862,11863,11874,11864" onclick="lightbox" navigation="yes" nav_style="arrow" auto_height="yes"][kc_spacing height="20" _id="138530"][kc_column_text _id="884372"]Applications
[/kc_column_text][kc_column_text _id="719495"]- Medical imaging: magnetic (MRI), nuclear (SPECT, PET)
- Therapy: anticancer nanodrugs, tumor radiosensibilization, photodynamic therapy
Team members
[/kc_column_text][kc_spacing height="20" _id="72649"][kc_column_text _id="96309"]{slide=Permanent members}
- Véronique BERARD, AP
- Julien BOUDON, AP
- Coralie FEVRE, Administrative & Financial Manager
- Michaële HERBST, AE
- Lionel MAURIZI, R
- Nadine MILLOT, FP
- Raminfar Al RAFRAFIN, T (50%)
- Lucien SAVIOT, SR
{/slide}
[/kc_column_text][kc_spacing height="20" _id="34060"][kc_column_text _id="58525"]{slide=Non-permanent members}
- Margaux DESSEIGNE, post-doctorante
- Eduardo HERNANDO ABAD, PhD student
- Amira MAHMOUD, PhD student
- Célia MARETS, PhD student
- Mélanie ROMAIN, PhD student
- Aicha HAMIDI, Master student
- Mohammad SIDDIQUI, Master student
Associated collaborators
- Nicole ABOU HAMAD, PhD student (Agrosup)
- Laroussi CHAABANE, Postdoctoral fellow (Agrosup)
- Damien GOULLEY, PhD student (Pharma)
- Alan ZERROUKI, PhD student (Interface/PMDM)
{/slide}
[/kc_column_text][kc_spacing height="20" _id="679858"][kc_column_text _id="413894"]{slide=Scientific guests}
BH2N team has welcome
Dr. Mitsunori YADA (Saga University, Japan)
Department of Chemistry and Applied Chemistry
from May 27 to August 26 2019
Details: Dpt. Chem. Univ. Saga's website
BH2N team has welcome
Prof. Dr. Gerold Schneider(Technische Universität Hamburg, Germany)
Head of Institute of Advanced Ceramics
From June 18th to July 13th 2018
Details:
Institute Advanced Ceramics' website
BH2N team has welcome
Dr. Katrin Löschner(Technical University of Denmark, Denmark)National Food InstituteResearch Group for Nano-Bio Science
From 3rd to May 29th 2018
More details:K. Löschner's webpage{/slide}
[/kc_column_text][kc_spacing height="20" _id="366384"][kc_column_text _id="63320"]{slide=Former members}
- Daniel AYMES (Associate Professor)
- Vanessa BELLAT (PhD student)
- Frédéric BOUYER (Assistant Professor)
- Thomas COURANT (Postdoctoral fellow, 2014-2015)
- Florent CREVAT (PhD student, 2013-2017)
- Moustafa EL KASS (Postdoctoral teaching and research assistant, 2014-2015)
- Jordan GUICHARD (PhD student CEA Valduc, 2012-2015)
- Sullivan GUY (Master's student, 2021)
- Gautier LAURENT (Postdoctoral fellow, 2016-2017)
- Alexis LOISEAU (PhD student, 2014-2017)
- Annette LUCE (PhD student 2016-2020)
- Renée MAYAP TALOM (Postdoctoral fellow)
- Léa PAGEARD (Master's student, 2021)
- Anne-Laure PAPA (PhD student)
- Jérémy PARIS (PhD student)
- Roy ROUKOS (PhD student)
- Yasmine SAIBI (Research engineer)
- Fadoua SALLEM (PhD student then Post-doctal fellow)
- Fariza SI AHMED (PhD student, 2013-2016)
- Nimisha SINGH (PhD student, Raman-Charpak fellowship 2017-2018, Postdoctoral fellow, 2020-2021)
- Sruthi SUDHAKARAN (PhD student, Raman-Charpak fellowship 2015-2016)
- Guillaume THOMAS (PhD student, 2012-2015)
- Mathieu VARACHE (PhD student)
{/slide}
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