(Bio-)Hybrid Nanoparticles & Nanostructures BH2N
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(Bio-)Hybrid Nanoparticles & Nanostructures (BH2N) is a group of the Nanosciences department from the laboratory ICB. It is lead by Nadine Millot and includes different activities. |
Nadine MILLOT
Group head
nadine.millot[at]u-bourgogne.fr
Tél : +333 80 39 59 37
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Post-doc offer Are you interested in a post-doctoral position in nanomedicine? Apply the offer by clicking the image on the left (pdf file, 474 Ko). |
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Interested in nanos? The French Nanomedicine Society (SFNano), and the French national Competency Cluster in Nanoscience (C’Nano) organize together their annual meetings in Dijon this December Click on the image on the left for more details (on the dedicated website). |
- SPIONs-phtalocyanine (Pc) nanohybrids developed as bimodal contrast agents for optical imaging (OI) and magnetic resonance imaging (MRI)
- SPIONs Nanohybrids surface modification by 3,4-dihydroxy-L-phenylalanine (LDOPA) or 3,4-dihydroxyhydrocinnamic acid (DHCA)
- SPIONs-LDOPA-PEG2000-MANOTA[64Cu] Nanohybrids evaluated in vitro and in vivo by MRI-PET
- Protein grafting at the surface of bimodal SPIONs to target cardiovascular diseases and monitor them by MRI-PET (cardiotoxicity induced by chemotherapy)
- Combination of TiONts + AuNPs to optimize the nanoplatform dedicated to the radiosensibilization of prostate cancer
- Neurodegenerative diseases: peroxisomal and mitochondrial targeting with multifunctional SPIONs
Related information: Chem. Commun. 2011, Chem. Commun. 2013, RSC. Adv. 2015, J. Biomed. Nanotechnol. 2015, EQUIPEX IMAPPI
Contacts: L. Maurizi, J. Boudon, N. Millot
- TiONts-SPIONs: MRI-detectable nanocarriers
- TiONts-phthalocyanine (Pc): promising optical imaging (OI)-detectable nanocarriers
- TiONts-docetaxel (DTX): concentration of a radiosensitzing nanocarrier into tumors
- TiONts-DOTA: nanohybrids biodistribution by SPECT-CT nuclear imaging
Related information: J. Phys. Chem. C 2011, RSC. Adv. 2015, Nanomedicine Ed. One Central Press 2014, Radiother. Oncol. 2013, Eur. J. Cancer 2014
- Controlled synthesis, reproducible and 99% pure
- TiONrs functionalization by polyethylene glycol (PEG) to graft proteins
- Lysine coupling: cellular adhesion
Related information: Dalton Trans. 2015, Brevet 2014 WO 2014/079890
- High yield synthesis of dispersed MSNs
- Improvement of the structural stability of MSNs
- Study of the influence of surface chemistry on the dispersion of MSNs and the encapsulation of drugs
- Study of the influence of surface chemistry on MSNs cytotoxicity (preliminary data)
- Development of MSNs-gold nanoparticles (AuNPs) nanohybrids or (AuNPs) for pH-sensitive drug delivery (by pH-cleavable bonds)
- in vitro and in vivo evaluation of the best formulations of MSNs
Related information: J. Non-Cryst. Solids 2015, J. Nanopart. Res. 2015
Contact: F. Bouyer
- Random LASERs
- Understanding of the catalyzed growth of doped TiO2 nanostructures
Related information: Optics Express 2012
Contact: D. Chaumont
- Cytotoxicity assays (MTT, Alamar blue, kinetics of RNA synthesis)
- Genotoxicity assays (comet assay, Ames assay, micronucleus assays)
- Carcinogenicity assays (cell transformation assay)
- Study, understanding and control of nanomaterial-protein interactions
Related information: Nanotoxicology 2013, plateforme “NanoCare Bourgogne", Nanoscale 2014, Biomaterials Science 2015
Contacts: L. Maurizi, N. Millot
Means & applications
The group has different elaboration and characterization techniques dedicated to the engineered nanoparticles and nanostructures.
Elaboration
Characterization
Applications
- Medical imaging: magnetic (MRI), nuclear (SPECT, PET)
- Therapy: anticancer nanodrugs, tumor radiosensibilization, photodynamic therapy
- Energy (solar cells, lithium batteries…), environment
Team members
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BH2N team welcomes Dr. Mitsunori YADA (Saga University, Japan) Department of Chemistry and Applied Chemistry from May 27 to August 26 2019 Details: Dpt. Chem. Univ. Saga’s website |
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BH2N team has welcome Prof. Dr. Gerold Schneider(Technische Universität Hamburg, Germany) Head of Institute of Advanced Ceramics From June 18th to July 13th 2018 Details: Institute Advanced Ceramics’ website |
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BH2N team has welcome Dr. Katrin Löschner(Technical University of Denmark, Denmark) Research Group for Nano-Bio Science |
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