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Fiche de : Nadine MILLOT

Département :
Nanosciences


Fonction :

Full Professor (PR1)



Localisation :

Office: C418A

Tél. : +33-3-80-39-59-37
E-mail : nmillot@u-bourgogne.fr

Until 2007: The originality of the approach I have undertaken to synthesize and study nanomaterials was to jointly control the morphology, the size distribution, the nature of the interfaces and the stoichiometry of the products. Indeed, many controversies in literature come from the non-control of one of these parameters (evolution of the lattice parameters, phase transition temperatures…). Some of these controversies have thus been excluded thanks to the approach I have developed.

After 2007 (after my habilitation): I refocused my work to initiate, in my laboratory, a new thematic about bioapplications of nanopowders.

Head of Resarch Team (Bio-)hybrid nanoparticles & nanostructures BH2N

The key nanomaterials studied are:

  • SPIONs (SuperParamagnetic Iron Oxide Nanoparticles) for multimodal imaging (MRI/PET and MRI/optical imaging). Two strengths are put to use (i) the originality of their simultaneous synthesis and colloidal stabilization in one step through a hydrothermal synthesis device working continuously (synthesis time <10 s, conditions T, P up to the supercritical water field) and (ii) the association of these nanoparticles with innovative chelating agents (NODAGA, MANOTA etc.) or innovative fluorophores (phtalocyanine in particular).
  • Titanate nanotubes (TiONts) that few teams in the world are able to synthesize. For the first time, these nanoparticles are developed for applications related to their ability to be internalized in various cell types. They have proven themselves for DNA transfection and radiosensitizing of tumors (glioblastoma and prostate cancer).

> Curriculum Vitae (English)

  • Principal investigator of a scientific project supported by joint funds through the CNRS/Burgundy Council/University of Burgundy trilateral agreement: 3MIM (« Marquage de Molécules par les Métaux pour l’Imagerie Médicale », in English « Labelling of Molecules with Metals for Medical Imaging »), Project: « Multifonctionnal nanomaterials for biomedical applications »:
    This project involves collaborative efforts from 19 researchers spread over three laboratories of the University of Burgundy (ICB, ICMUB, LE2I), two hospitals (CHU de Dijon and CGFL) and a biotechnology company (NVH Medicinal)
  • Principal investigator and founder of « Bourgogne-Nanocare » platform, Satt Grand Est (Welience), in collaboration with INSERM U866: development of cytotoxicity assays, genotoxicity assays, DCFDA cellular ROS detection assays, ecotoxicity assays (Zebrafish), biodistribution studies (MRI, PET, SPECT, OI) to evaluate nanoparticle toxicity or safety profile

> Nanocare platform

  • Principal investigator of a thematic in the Equipex IMAPPI (Integrated Magnetic resonance And Positron emission tomography in Preclinical Imaging) funded by the General Commission for Investment and the French Government- One scientific project in progress for the development of bimodal contrast agents based on SPIONs (MRI/PET)

> Equipex IMAPPI

  • Principal investigator of two projects with the radiotherapy department of the French Comprehensive Cancer Center
    « Titanate nanotubes as new nanovectors of radiosensitizers: internalization, radiosensitizing and biodistribution of these nanohybrids, vectors of docetaxel, in case of prostate cancers in nude mouse model  » (co-principal investigator Prof. G. Créhange). Project funded by the Cancer League « Grand-Est » (2012/2013)
    « Nanohybrids based on titanate nanotubes and gold nanoparticles as new radiosensitizers of prostate cancer ». Project funded by the Greater East Cancer Research Clusters (2015/2017)
  • Principal investigator of an agreement with the biotechnology company NVH Medicinal (signed in 2010 for 4 years and renewed in 2015). Scientific topic: nanoparticles, proteins and regenerative medicine

> NVH Medical

  • Principal investigator of a scientific theme inside PARI2 Nano2Bio (2014/2020): « Nanoparticles for the vectorization of drugs and for regenerative medicine »

195 communications:

  • 28 invited conferences (14 in international congresses)
  • 13 invited seminars (5 abroad)
  • 13 popular science lectures (with personal invitation)

Awards:

  • European Ceramic Society award (Brighton, UK), 1998
  • French Ceramic Society award (Paris, France), 1998
  • JECH award (Paris, France, Heterogeneous Kinetic), 1998

Principal investigator and founder of the national training action ANF NanoMed 2018

Member of the scientific committee of ICONAN 2016, 2017 and 2018

Some upcoming or recent communications:

  • Development of novel versatile theranostic platforms: from SPIONs to titanate nanotubes and tantalum oxides, J. Boudon, L. Maurizi, F. Sallem, N. Millot*, SFNano, Montpellier (France), 3-5 décembre 2018
  • Continuous and reproducible functionalized nanoparticles as MRI-PET contrast agents: towards targeting multimodal probes? G. Thomas, J. Boudon, L. Maurizi, M. Moreau, P. Walker, A. Oudot, F. Demoisson, F. Denat, F. Brunotte, N. Millot*, BioNanomed 2016, 20-22 mars 2017, Krems (Austria)
  • Development of titanate nanotubes to vectorize docetaxel or combined with Au nanoparticles for the treatment of prostate cancer, A. Loiseau, J. Boudon, C. Mirjolet, G. Créhange, B. Collin, A. Oudot, S. Roux, N. Millot*, EMRS, 2-5 mai 2016, Lille (France)
  • Biomedical applications of nanoparticles: new nanoplatforms for theranostic. Some examples in oncology, cardiovascular diseases, gene therapy and neurosciences, N. Millot, « IV Congreso Internacional de Salud Integral, IX Congreso Francés de Ciencias y Tecnologías Avanzadas, I Congreso Internacional de l’APSP”, 27-29 October 2016, Santa Marta (Colombia), Invited Conference
  • Innovative SPIONs for multimodal imaging: MRI/PET and MRI/optical imaging, J. Boudon, G. Thomas, J. Paris, L. Maurizi, N. Millot*, ICONAN 2016, 28-30 September 2016, Paris (France)
  • Preclinical development of a titanate-docetaxel nanohybrid for the treatment of prostate cancer, J. Boudon, C. Mirjolet, A. Loiseau, G. Créhange, N. Millot*, MRS Fall Meeting, 29 novembre-4 December 2015, Boston (USA)

Accepted publication: Journal of Nanoscience and Nanotechnology (2019)

  • Publications extracted from Web of Science:
  • Researcher unique identifiers:

Google Scholar

ORCID

Researcher ID

Scopus

  • Guest Editor of a Special issue of Nanomaterials (19 papers published)

> Special Issue « Biomedical Applications of Nanoparticles »

  • 1 international patent « Titanate nanostructures for regenerative medicine and tissue engineering« , WO 2014/079890 A1 Millot Nadine, Vandroux David, Bellat Vanessa
  • 12 conference proceedings (two of them referenced by Sci. Finder Scholar)
  • 2 book chapters:
    * Nanomedicine (One Central Press, UK 2014) « Titanate nanotubes as a versatile platform for nanomedicine » J. Boudon, A.L. Papa, J. Paris, N. Millot* Unraveling the Safety Profile of Nanoscale Particles and Materials – From Biomedical to Environmental Applications, Edited by Andreia C. Gomes and Marisa P. Sarria, InTech – open science, 2018 ISBN 978-953-51-3940-9, Published: March 21, 2018 « Toxicological risk assessment of emerging nanomaterials: cytotoxicity, cellular uptake, effects on biogenesis and cell organelle activity, acute toxicity and biodistribution of oxide nanoparticles » L. Maurizi, A.L. Papa, J. Boudon, S. Sruthi, B. Pruvot, D. Vandroux, J. Chluba, G. Lizard, N. Millot, Chapter 2,

  • 1 popular article: « Nanoparticules : de nouveaux outils thérapeutiques déjà éprouvés. Danger ou formidable espoir pour la société ? » N. Millot, Réalités Pédiatriques – n° 207_Janvier 2017

Relevant publications of the last years:

  • « Taxane-grafted metal-oxide nanoparticles as a new theranostic tool against cancer: the promising example of docetaxel-functionalized titanate nanotubes in preclinical development on prostate tumors », A. Loiseau, J. Boudon, C. Mirjolet, G. Créhange, N. Millot, Adv. Healthcare Mater. 1700245 (2017)
  • « One-step continuous synthesis of functionalized magnetite nanoflowers », G. Thomas, F. Demoisson, R. Chassagnon, E. Popova, N. Millot, Nanotechnology 27, 135604-135619 (2016)
  • « Influence of surface charge and polymer coating on internalization and biodistribution of PEG-modified iron oxide nanoparticles », L. Maurizi, A.L. Papa, L. Dumont, F. Bouyer, D. Vandroux, P. Walker, N. Millot, J. Biomed. Nanotechnol. 11, 126–136 (2015)
  • « Titanate nanotubes: towards a novel and safer nanovector for cardiomyocytes », A.L. Papa, L. Dumont, D. Vandroux, N. Millot, Nanotoxicology 7 (6), 1131 (2013)
  • « The radiosensitization effect of titanate nanotubes as a new tool in radiation therapy for glioblastoma: a proof-of-concept », C. Mirjolet, A.L. Papa, G. Créhanges, G. Truc, P. Maingon, N. Millot, Radioth. Oncol. 108, 136 (2013)

Principal advisor of International Relations of ESIREM, Materials Department

Principal advisor of ESIREM internships, Materials Department (for the past 12 years)

Control of the placement of 45 students each year, co-writing of a quality charter on internships, advice for students, personal placement of 5 to 10 students each year, administrative follow-up of internships, choice of the tutors at the university, organization of the oral defenses.

Teaching duties 2015/2016 : 

  • ESIREM 3rd year, « Cristallography », Lecture (15 h), Tutorial (24 h)
  • ESIREM 4th and 5th years, « Responsibility of internships » (34 h)
  • ESIREM 4th and 5th years, « Ceramic », Tutorial (6 h), Practical Work (56 h)
  • BSc in Chemistry (Licence 3), « Nanopowders », Lecture (18 h), Practical Work (21 h)
  • Master 2 Nanosciences and Master 2 CDM (Control and Durability of Materials)
    « The impact of nanomaterials on Health and Safety », Lecture (12 h)
    « Nanohybrids: Biomedical Applications », Lecture (6 h)

Author of an educational book, Lavoisier Editions (Paris, February 2014) « Cristallographie Géométrique – Cours – Exercices et Problèmes corrigés » (266 pages), Nadine MILLOT, Jean-Claude NIEPCE, Graduate-level, Engineering school

  • Member of the steering committee of the C’Nano Grand-Est (since 2018)
  • Member of the steering committee of the C’Nano France (since 2018)

  • Selection Committee Chair for Chemistry of the University of Burgundy 31/32/33 sections
  • Member of the scientific committee of the GIS Pharmaco-Imagery (since its creation in 2016)
  • Member of the BFCare cluster (since 2008)
  • Elected member of CNU, section 31 (alternate) (in 2015-2016)
  • Expert of the ANR agency, of the F.R.S.-FNRS (Belgium) and of several universities

Until 2007: The originality of the approach I have undertaken to synthesize and study nanomaterials was to jointly control the morphology, the size distribution, the nature of the interfaces and the stoichiometry of the products. Indeed, many controversies in literature come from the non-control of one of these parameters (evolution of the lattice parameters, phase transition temperatures…). Some of these controversies have thus been excluded thanks to the approach I have developed.

After 2007 (after my habilitation): I refocused my work to initiate, in my laboratory, a new thematic about bioapplications of nanopowders.

Head of Resarch Team (Bio-)hybrid nanoparticles & nanostructures BH2N

The key nanomaterials studied are:

  • SPIONs (SuperParamagnetic Iron Oxide Nanoparticles) for multimodal imaging (MRI/PET and MRI/optical imaging). Two strengths are put to use (i) the originality of their simultaneous synthesis and colloidal stabilization in one step through a hydrothermal synthesis device working continuously (synthesis time <10 s, conditions T, P up to the supercritical water field) and (ii) the association of these nanoparticles with innovative chelating agents (NODAGA, MANOTA etc.) or innovative fluorophores (phtalocyanine in particular).
  • Titanate nanotubes (TiONts) that few teams in the world are able to synthesize. For the first time, these nanoparticles are developed for applications related to their ability to be internalized in various cell types. They have proven themselves for DNA transfection and radiosensitizing of tumors (glioblastoma and prostate cancer).

> Curriculum Vitae (English)

  • Principal investigator of a scientific project supported by joint funds through the CNRS/Burgundy Council/University of Burgundy trilateral agreement: 3MIM (« Marquage de Molécules par les Métaux pour l’Imagerie Médicale », in English « Labelling of Molecules with Metals for Medical Imaging »), Project: « Multifonctionnal nanomaterials for biomedical applications »:
    This project involves collaborative efforts from 19 researchers spread over three laboratories of the University of Burgundy (ICB, ICMUB, LE2I), two hospitals (CHU de Dijon and CGFL) and a biotechnology company (NVH Medicinal)
  • Principal investigator and founder of « Bourgogne-Nanocare » platform, Satt Grand Est (Welience), in collaboration with INSERM U866: development of cytotoxicity assays, genotoxicity assays, DCFDA cellular ROS detection assays, ecotoxicity assays (Zebrafish), biodistribution studies (MRI, PET, SPECT, OI) to evaluate nanoparticle toxicity or safety profile

> Nanocare platform

  • Principal investigator of a thematic in the Equipex IMAPPI (Integrated Magnetic resonance And Positron emission tomography in Preclinical Imaging) funded by the General Commission for Investment and the French Government- One scientific project in progress for the development of bimodal contrast agents based on SPIONs (MRI/PET)

> Equipex IMAPPI

  • Principal investigator of two projects with the radiotherapy department of the French Comprehensive Cancer Center
    « Titanate nanotubes as new nanovectors of radiosensitizers: internalization, radiosensitizing and biodistribution of these nanohybrids, vectors of docetaxel, in case of prostate cancers in nude mouse model  » (co-principal investigator Prof. G. Créhange). Project funded by the Cancer League « Grand-Est » (2012/2013)
    « Nanohybrids based on titanate nanotubes and gold nanoparticles as new radiosensitizers of prostate cancer ». Project funded by the Greater East Cancer Research Clusters (2015/2017)
  • Principal investigator of an agreement with the biotechnology company NVH Medicinal (signed in 2010 for 4 years and renewed in 2015). Scientific topic: nanoparticles, proteins and regenerative medicine

> NVH Medical

  • Principal investigator of a scientific theme inside PARI2 Nano2Bio (2014/2020): « Nanoparticles for the vectorization of drugs and for regenerative medicine »

195 communications:

  • 28 invited conferences (14 in international congresses)
  • 13 invited seminars (5 abroad)
  • 13 popular science lectures (with personal invitation)

Awards:

  • European Ceramic Society award (Brighton, UK), 1998
  • French Ceramic Society award (Paris, France), 1998
  • JECH award (Paris, France, Heterogeneous Kinetic), 1998

Principal investigator and founder of the national training action ANF NanoMed 2018

Member of the scientific committee of ICONAN 2016, 2017 and 2018

Some upcoming or recent communications:

  • Development of novel versatile theranostic platforms: from SPIONs to titanate nanotubes and tantalum oxides, J. Boudon, L. Maurizi, F. Sallem, N. Millot*, SFNano, Montpellier (France), 3-5 décembre 2018
  • Continuous and reproducible functionalized nanoparticles as MRI-PET contrast agents: towards targeting multimodal probes? G. Thomas, J. Boudon, L. Maurizi, M. Moreau, P. Walker, A. Oudot, F. Demoisson, F. Denat, F. Brunotte, N. Millot*, BioNanomed 2016, 20-22 mars 2017, Krems (Austria)
  • Development of titanate nanotubes to vectorize docetaxel or combined with Au nanoparticles for the treatment of prostate cancer, A. Loiseau, J. Boudon, C. Mirjolet, G. Créhange, B. Collin, A. Oudot, S. Roux, N. Millot*, EMRS, 2-5 mai 2016, Lille (France)
  • Biomedical applications of nanoparticles: new nanoplatforms for theranostic. Some examples in oncology, cardiovascular diseases, gene therapy and neurosciences, N. Millot, « IV Congreso Internacional de Salud Integral, IX Congreso Francés de Ciencias y Tecnologías Avanzadas, I Congreso Internacional de l’APSP”, 27-29 October 2016, Santa Marta (Colombia), Invited Conference
  • Innovative SPIONs for multimodal imaging: MRI/PET and MRI/optical imaging, J. Boudon, G. Thomas, J. Paris, L. Maurizi, N. Millot*, ICONAN 2016, 28-30 September 2016, Paris (France)
  • Preclinical development of a titanate-docetaxel nanohybrid for the treatment of prostate cancer, J. Boudon, C. Mirjolet, A. Loiseau, G. Créhange, N. Millot*, MRS Fall Meeting, 29 novembre-4 December 2015, Boston (USA)

Innovative Magnetic Nanoparticles for PET/MRI Bimodal Imaging

Guillaume Thomas, Julien Boudon, Lionel Maurizi, Mathieu Moreau, Paul Walker, Isabelle Severin, Alexandra Oudot, Christine Goze, Sophie Poty, Jean-Marc Vrigneaud, Frederic Demoisson, Franck Denat, Francois Brunotte, Nadine Millot,
Journal : ACS Omega - n° 4 - 2019 - 2637-2648

Polydopamine Modified Superparamagnetic Iron Oxide Nanoparticles as Multifunctional Nanocarrier for Targeted Prostate Cancer Treatment

Nimisha Singh, Fadoua Sallem, Celine Mirjolet, Thomas Nury, Suban Kumar Sahoo, Nadine Millot, Rajender Kumar,
Journal : Nanomaterials - n° 9 - 2019 - 138

Elaboration of Trans-Resveratrol Derivative-Loaded Superparamagnetic Iron Oxide Nanoparticles for Glioma Treatment

Fadoua Sallem, Rihab Haji, Dominique Vervandier-Fasseur, Thomas Nury, Lionel Maurizi, Julien Boudon, Gerard Lizard, Nadine Millot,
Journal : Nanomaterials - n° 9 - 2019 - 287

Dielectric behavior of a lead-free electroceramics Ba1-xEr2x/3(Ti1-yZry)O-3

F. Si-Ahmed, K. Taibi, O. Bidault, N. Millot,
Journal : J. Mater. Sci.-Mater. Electron. - n° 29 - 2018 - 10154-10163

In vitro interaction and biocompatibility of titanate nanotubes with microglial cells

S. Sruthi, A. Loiseau, J. Boudon, F. Sallem, L. Maurizi, P. V. Mohanan, G. Lizard, N. Millot,
Journal : Toxicol. Appl. Pharmacol. - n° 353 - 2018 - 74-86

Cellular interactions of functionalized superparamagnetic iron oxide nanoparticles on oligodendrocytes without detrimental side effects: Cell death induction, oxidative stress and inflammation

S. Sruthi, L. Maurizi, T. Nury, F. Sallem, J. Boudon, J. M. Riedinger, N. Millot, F. Bouyer, G. Lizard,
Journal : Colloid Surf. B-Biointerfaces - n° 170 - 2018 - 454-462

Zinc oxide nanoparticles mediated cytotoxicity, mitochondrial membrane potential and level of antioxidants in presence of melatonin

S. Sruthi, N. Millot, P. V. Mohanan,
Journal : Int. J. Biol. Macromol. - n° 103 - 2017 - 808-818

Docetaxel-titanate nanotubes enhance radiosensitivity in an androgen-independent prostate cancer model

Celine Mirjolet, Julien Boudon, Alexis Loiseau, Sandy Chevrier, Romain Boidot, Alexandra Oudot, Bertrand Collin, Etienne Martin, Pattayil Alias Joy, Nadine Millot, Gilles Crehange,
Journal : Int. J. Nanomed. - n° 12 - 2017 - 6357-6364

Normal and relaxor ferroelectric behavior in the Ba1-xPbx(Ti1-yZry)O-3 solid solutions

F. Si Ahmed, K. Taibi, O. Bidault, N. Geoffroy, N. Millot,
Journal : J. Alloy. Compd. - n° 693 - 2017 - 245-256

Effect of mechanical stirring and temperature on dynamic hydrothermal synthesis of titanate nanotubes

Fadoua Sallem, Remi Chassagnon, Adel Megriche, Mohamed El Maaoui, Nadine Millot,
Journal : J. Alloy. Compd. - n° 722 - 2017 - 785-796

Synthesis and characterization of chitosan-coated titanate nanotubes: towards a new safe nanocarrier

Fadoua Sallem, Julien Boudon, Olivier Heintz, Isabelle Severin, Adel Megriche, Nadine Millot,
Journal : Dalton Trans. - n° 46 - 2017 - 15386-15398

Taxane-Grafted Metal-Oxide Nanoparticles as a New Theranostic Tool against Cancer: The Promising Example of Docetaxel-Functionalized Titanate Nanotubes on Prostate Tumors

Alexis Loiseau, Julien Boudon, Celine Mirjolet, Gilles Crehange, Nadine Millot,
Journal : Adv. Healthc. Mater. - n° 6 - 2017 - 1700245

Tetrazine Click Chemistry for the Modification of 1-Hydroxy-1,1-methylenebisphosphonic Acids: Towards Bio-orthogonal Functionalization of Gold Nanoparticles

Romain Aufaure, Julie Hardouin, Nadine Millot, Laurence Motte, Yoann Lalatonne, Erwann Guenin,
Journal : Chem.-Eur. J. - n° 22 - 2016 - 16022-16027

One-step continuous synthesis of functionalized magnetite nanoflowers

G. Thomas, F. Demoisson, R. Chassagnon, E. Popova, N. Millot,
Journal : Nanotechnology - n° 27 - 2016 - 135604

Efficient functionalization of magnetite nanoparticles with phosphonate using a one-step continuous hydrothermal process

Guillaume Thomas, Frederic Demoisson, Julien Boudon, Nadine Millot,
Journal : Dalton Trans. - n° 45 - 2016 - 10821-10829

Immobilized Pd on magnetic nanoparticles bearing proline as a highly efficient and retrievable Suzuki-Miyaura catalyst in aqueous media

E. Nehlig, B. Waggeh, N. Millot, Y. Lalatonne, L. Motte, E. Guenin,
Journal : Dalton Trans. - n° 44 - 2015 - 501-505

Dispersion of titanate nanotubes for nanomedicine: comparison of PEI and PEG nanohybrids

Anne-Laure Papa, Julien Boudon, Vanessa Bellat, Alexis Loiseau, Harender Bisht, Fadoua Sallem, Remi Chassagnon, Veronique Berard, Nadine Millot,
Journal : Dalton Trans. - n° 44 - 2015 - 739-746

Preclinical development of a docetaxel nanocarrier to enhance prostate cancer radiosensitivity.

Gilles Crehange, Julien Boudon, Romain Boidot, Sandy Chevrier, Cecile Dalban, Alexis Loiseau, Bertrand Collin, Alexandra Oudot, Thomas Gauthier, Nadine Millot, Celine Mirjolet,
Journal : J. Clin. Oncol. - n° 33 - 2015 -

Functionalized Fe3O4 nanoparticles: influence of ligand addition sequence and pH during their continuous hydrothermal synthesis

G. Thomas, F. Demoisson, O. Heintz, N. Geoffroy, L. Saviot, N. Millot,
Journal : RSC Adv. - n° 5 - 2015 - 78614-78624

A multi-step mechanism and integrity of titanate nanoribbons

Vanessa Bellat, Remi Chassagnon, Olivier Heintz, Lucien Saviot, David Vandroux, Nadine Millot,
Journal : Dalton Trans. - n° 44 - 2015 - 1150-1160

Influence of Surface Charge and Polymer Coating on Internalization and Biodistribution of Polyethylene Glycol-Modified Iron Oxide Nanoparticles

Lionel Maurizi, Anne-Laure Papa, Laure Dumont, Frederic Bouyer, Paul Walker, David Vandroux, Nadine Millot,
Journal : J. Biomed. Nanotechnol. - n° 11 - 2015 - 126-136

Phthalocyanine-titanate nanotubes: a promising nanocarrier detectable by optical imaging in the so-called imaging window

J. Paris, Y. Bernhard, J. Boudon, O. Heintz, N. Millot, R. A. Decreau,
Journal : RSC Adv. - n° 5 - 2015 - 6315-6322

The enhancement of radiotherapy efficacy with docetaxel-titanate nanotubes as a new nanohybrid for localized high risk prostate cancer

C. Mirjolet, J. Boudon, A. Loiseau, S. Chevrier, T. Gautier, R. Boidot, J. Paris, N. Millot, G. Crehange,
Journal : Eur. J. Cancer - n° 50 - 2014 - 67-67

Control of barium ferrite decomposition during spark plasma sintering: Towards nanostructured samples with anisotropic magnetic properties

Simona Ovtar, Sophie Le Gallet, Ludivine Minier, Nadine Millot, Darja Lisjak,
Journal : J. Eur. Ceram. Soc. - n° 34 - 2014 - 337-346

Fast and continuous synthesis of nanostructured iron spinel in supercritical water: influence of cations and citrates

L. Maurizi, F. Bouyer, M. Ariane, R. Chassagnon, N. Millot,
Journal : RSC Adv. - n° 4 - 2014 - 45673-45678

The radiosensitization effect of titanate nanotubes as a new tool in radiation therapy for glioblastoma: A proof-of-concept

C. Mirjolet, A. L. Papa, G. Crehange, O. Raguin, C. Seignez, C. Paul, G. Truc, P. Maingon, N. Millot,
Journal : Radiother. Oncol. - n° 108 - 2013 - 136-142

Magneto-optical nanomaterials: a SPIO-phthalocyanine scaffold built step-by-step towards bimodal imaging

Julien Boudon, Jeremy Paris, Yann Bernhard, Elena Popova, Richard A. Decreau, Nadine Millot,
Journal : Chem. Commun. - n° 49 - 2013 - 7394-7396

Titanate nanotubes: towards a novel and safer nanovector for cardiomyocytes

Anne-Laure Papa, Laure Dumont, David Vandroux, Nadine Millot,
Journal : Nanotoxicology - n° 7 - 2013 - 1131-1142

THE RADIOSENSITIZATION EFFECT OF TITANATE NANOTUBES AS A PROMISING TOOL IN RADIOTHERAPY: A PROOF OF CONCEPT

C. Mirjolet, A. L. Papa, G. Crehange, J. Boudon, O. Raguin, C. Seignez, C. Paul, G. Truc, N. Millot, P. Maingon,
Journal : Radiother. Oncol. - n° 104 - 2012 - 24-24

Deposition and characterization of cold sprayed nanocrystalline NiTi

S. Tria, O. Elkedim, R. Hamzaoui, X. Guo, F. Bernard, N. Millot, O. Rapaud,
Journal : Powder Technol. - n° 210 - 2011 - 181-188

Oxygen stoichiometry control of nanometric oxide compounds: The case of titanium ferrites

N. Millot, P. Perriat,
Journal : J. Solid State Chem. - n° 184 - 2011 - 2776-2784

Synthesis of Titanate Nanotubes Directly Coated with USPIO in Hydrothermal Conditions: A New Detectable Nanocarrier

Anne-Laure Papa, Lionel Maurizi, David Vandroux, Paul Walker, Nadine Millot,
Journal : J. Phys. Chem. C - n° 115 - 2011 - 19012-19017

One step continuous hydrothermal synthesis of very fine stabilized superparamagnetic nanoparticles of magnetite

Lionel Maurizi, Frederic Bouyer, Jeremy Paris, Frederic Demoisson, Lucien Saviot, Nadine Millot,
Journal : Chem. Commun. - n° 47 - 2011 - 11706-11708

On the origin of the sigmoid shape in the UO2 oxidation weight gain curves

L. Quemard, L. Desgranges, V. Bouineau, M. Pijolat, G. Baldinozzi, N. Millot, J. C. Niepce, A. Poulesquen,
Journal : J. Eur. Ceram. Soc. - n° 29 - 2009 - 2791-2798

Synthesis and characterization of nanometric powders of UO2+x, (Th,U)O2+x and (La,U)O2+x

G. Rousseau, M. Fattahi, B. Grambow, L. Desgranges, F. Boucher, G. Ouvrard, N. Millot, J. C. Niepce,
Journal : J. Solid State Chem. - n° 182 - 2009 - 2591-2597

Easy Route to Functionalize Iron Oxide Nanoparticles via Long-Term Stable Thiol Groups

L. Maurizi, H. Bisht, F. Bouyer, N. Millot,
Journal : Langmuir - n° 25 - 2009 - 8857-8859

Effect of Reaction Parameters on Composition and Morphology of Titanate Nanomaterials

Anne-Laure Papa, Nadine Millot, Lucien Saviot, Remi Chassagnon, Olivier Heintz,
Journal : J. Phys. Chem. C - n° 113 - 2009 - 12682-12689

Inelastic neutron scattering due to acoustic vibrations confined in nanoparticles: Theory and experiment

Lucien Saviot, Caleb H. Netting, Daniel B. Murray, Stephane Rols, Alain Mermet, Anne-Laure Papa, Catherine Pighini, Daniel Aymes, Nadine Millot,
Journal : Phys. Rev. B - n° 78 - 2008 - 245426

Continuous hydrothermal synthesis of nanometric BaZrO3 in supercritical water

A. Aimable, B. Xin, N. Millot, D. Aymes,
Journal : J. Solid State Chem. - n° 181 - 2008 - 183-189

Temperature dependent photoluminescence of photocatalytically active titania nanopowders

Herrade Bieber, Pierre Gilliot, Mathieu Gallart, Nicolas Keller, Valerie Keller, Sylvie Begin-Colin, Catherine Pighini, Nadine Millot,
Journal : Catal. Today - n° 122 - 2007 - 101-108

In situ and time resolved study of the gamma/alpha-Fe2O3 transition in nanometric particles

T. Belin, N. Millot, N. Bovet, M. Gailhanou,
Journal : J. Solid State Chem. - n° 180 - 2007 - 2377-2385

Spark plasma sintering of cobalt ferrite nanopowders prepared by coprecipitation and hydrothermal synthesis

N. Millot, S. Le Gallet, D. Aymes, F. Bernard, Y. Grin,
Journal : J. Eur. Ceram. Soc. - n° 27 - 2007 - 921-926

Low-frequency Raman characterization of size-controlled anatase TiO2 nanopowders prepared by continuous hydrothermal syntheses

Catherine Pighini, Daniel Aymes, Nadine Millot, Lucien Saviot,
Journal : J. Nanopart. Res. - n° 9 - 2007 - 309-315

A detailed study of UO2 to U3O8 oxidation phases and the associated rate-limiting steps

G. Rousseau, L. Desgranges, F. Charlot, N. Millot, J. C. Niepce, M. Pijolat, F. Valdivieso, G. Baldinozzi, J. F. Berar,
Journal : J. Nucl. Mater. - n° 355 - 2006 - 10-20

Far-infrared absorption by acoustic phonons in titanium dioxide nanopowders

Daniel B. Murray, Caleb H. Netting, Lucien Saviot, Catherine Pighini, Nadine Millot, Daniel Aymes, Hsiang-Lin Liu,
Journal : J. Nanoelectron. Optoelectron. - n° 1 - 2006 - 92-98

Surface adsorption effects on the lattice expansion of copper nanocrystals

Y Champion, F Bernard, N Millot, P Perriat,
Journal : Appl. Phys. Lett. - n° 86 - 2005 - 231914

Hydrothermal synthesis of nanostructured inorganic powders by a continuous process under supercritical conditions

N Millot, B Xin, C Pighini, D Aymes,
Journal : J. European Ceram. Soc. - n° 25 - 2005 - 2013-2016

Structural variations as a function of surface adsorption in nanostructured particles

T Belin, N Millot, F Villieras, O Bertrand, JP Bellat,
Journal : J. Phys. Chem. B - n° 108 - 2004 - 5333-5340

Particle size dependency of ternary diagrams at the nanometer scale: Evidence of TiO2 clusters in Fe-based spinels

N Millot, D Aymes, F Bernard, JC Niepce, A Traverse, F Bouree, BL Cheng, P Perriat,
Journal : J. Phys. Chem. B - n° 107 - 2003 - 5740-5750

Apparent magic numbers in embedded Ti-O clusters

N Guigue-Millot, O Tillement, P Perriat,
Journal : Phys. Rev. B - n° 68 - 2003 - 113405

Sintering of copper nanopowers under hydrogen: an in situ X-ray diffraction analysis

Y Champion, F Bernard, N Guigue-Millot, P Perriat,
Journal : Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. - n° 360 - 2003 - 258-263

Mixed valences in nanometric ferrites investigated by resonant powder diffraction

J Lorimier, F Bernard, JC Niepce, N Guigue-Millot, O Isnard, JF Berar,
Journal : J. Appl. Crystallogr. - n° 36 - 2003 - 301-307

Control of grain size and morphologies of nanograined ferrites by adaptation of the synthesis route: mechanosynthesis and soft chemistry

N Guigue-Millot, S Begin-Colin, Y Champion, MJ Hytch, G Le Caer, P Perriat,
Journal : J. Solid State Chem. - n° 170 - 2003 - 30-38

Segregation phenomena in nanometric titanium ferrites: Complementarity of different experimental techniques (DRX, XPS, EXAFS...)

N Guigue-Millot, F Bernard, JC Niepce, A Traverse, P Perriat,
Journal : J. Phys. IV - n° 12 - 2002 - 473-479

Influence of grain size, oxygen stoichiometry, and synthesis conditions on the gamma-Fe2O3 vacancies ordering and lattice parameters

T Belin, N Guigue-Millot, T Caillot, D Aymes, JC Niepce,
Journal : J. Solid State Chem. - n° 163 - 2002 - 459-465

X-ray diffraction analysis in situ of the evolution of the lattice parameter of a nanometric ferrite, gamma-Fe2O3 at different water vapor pressures

T Belin, N Guigue-Millot, JP Bellat, JC Niepce,
Journal : J. Phys. IV - n° 12 - 2002 - 487-497

Chemical heterogeneities in nanometric titanomagnetites prepared by soft chemistry and studied ex situ: Evidence for Fe-segregation and oxidation kinetics

N Guigue-Millot, Y Champion, MJ Hytch, F Bernard, S Begin-Colin, P Perriat,
Journal : J. Phys. Chem. B - n° 105 - 2001 - 7125-7132

Evidence for the Verwey transition in highly nonstoichiometric nanometric Fe-based ferrites

N Guigue-Millot, N Keller, P Perriat,
Journal : Phys. Rev. B - n° 64 - 2001 - 012402

Characterization of ferrites synthesized by mechanical alloying and soft chemistry

N Millot, SB Colin, P Perriat, G Le Caer, R Welter, B Malaman,
Journal : Nanostruct. Mater. - n° 12 - 1999 - 641-644

XPS and EELS investigations of chemical homogeneity in nanometer scaled Ti-ferrites obtained by soft chemistry

P Perriat, E Fries, N Millot, B Domenichini,
Journal : Solid State Ion. - n° 117 - 1999 - 175-184

Dynamic segregation phenomena during oxidation of titanium ferrites

B Domenichini, P Perriat, J Merle, K Basset, N Guigue-Millot, S Bourgeois,
Journal : J. Mater. Chem. - n° 9 - 1999 - 1179-1183

Structure, cation distribution, and properties of nanocrystalline titanomagnetites obtained by mechanosynthesis: Comparison with soft chemistry

N Millot, S Begin-Colin, P Perriat, G Le Caer,
Journal : J. Solid State Chem. - n° 139 - 1998 - 66-78

Cation distribution in ferrites with spinel structure measured by anomalous powder diffraction

F Bernard, J Lorimier, V Nivoix, N Millot, P Perriat, JC Niepce, B Gillot, M Ferlet, JF Berar,
Journal : MATER SCI FORUM - n° - 1998 - 594-599

Application of resonant diffraction for determining cationic distribution of a nanometic titanium ferrite

F Bernard, J Lorimier, V Nivoix, N Millot, N Keller, P Perriat, JF Berar,
Journal : J. Phys. IV - n° 8 - 1998 - 99-107

Cation distribution in a titanium ferrite Fe2.75Ti0.25O4 measured by in-situ anomalous powder diffraction using Rietveld refinement

F Bernard, J Lorimier, V Nivoix, N Millot, P Perriat, B Gillot, JF Berar, JC Niepce,
Journal : J. Solid State Chem. - n° 141 - 1998 - 105-113

Correlation between the reactivity towards oxygen and the coercitivity in submicron vanadium ferrite spinels

V Nivoix, B Gillot, D Aymes, P Perriat, N Millot, S Rousseau, M Guyot,
Journal : J. Phys. IV - n° 7 - 1997 - 237-238

Experimental set up for determining the temperature-oxygen partial pressure conditions during synthesis of spinel oxide nanoparticles

D Aymes, N Millot, V Nivoix, P Perriat, B Gillot,
Journal : Solid State Ion. - n° 101 - 1997 - 261-264

Principal advisor of International Relations of ESIREM, Materials Department

Principal advisor of ESIREM internships, Materials Department (for the past 12 years)

Control of the placement of 45 students each year, co-writing of a quality charter on internships, advice for students, personal placement of 5 to 10 students each year, administrative follow-up of internships, choice of the tutors at the university, organization of the oral defenses.

Teaching duties 2015/2016 : 

  • ESIREM 3rd year, « Cristallography », Lecture (15 h), Tutorial (24 h)
  • ESIREM 4th and 5th years, « Responsibility of internships » (34 h)
  • ESIREM 4th and 5th years, « Ceramic », Tutorial (6 h), Practical Work (56 h)
  • BSc in Chemistry (Licence 3), « Nanopowders », Lecture (18 h), Practical Work (21 h)
  • Master 2 Nanosciences and Master 2 CDM (Control and Durability of Materials)
    « The impact of nanomaterials on Health and Safety », Lecture (12 h)
    « Nanohybrids: Biomedical Applications », Lecture (6 h)

Author of an educational book, Lavoisier Editions (Paris, February 2014) « Cristallographie Géométrique – Cours – Exercices et Problèmes corrigés » (266 pages), Nadine MILLOT, Jean-Claude NIEPCE, Graduate-level, Engineering school

  • Member of the steering committee of the C’Nano Grand-Est (since 2018)
  • Member of the steering committee of the C’Nano France (since 2018)

  • Selection Committee Chair for Chemistry of the University of Burgundy 31/32/33 sections
  • Member of the scientific committee of the GIS Pharmaco-Imagery (since its creation in 2016)
  • Member of the BFCare cluster (since 2008)
  • Elected member of CNU, section 31 (alternate) (in 2015-2016)
  • Expert of the ANR agency, of the F.R.S.-FNRS (Belgium) and of several universities
statut_ub:
batiment:
equipe_1:
OCS
fonction_equipe_1:
Agent(e) de service
mots_cles:
adresse:
onglets:
{tab=Carrière} # {tab=Projets} # {tab=Publications} # {tab=Communications} # {tab=Enseignements} # {tab=Administration} # {/tabs}
telephone:
+33-3-80-39-59-37
e-mail:
nmillot@u-bourgogne.fr
site_web:
departement:
a:1:{i:0;s:12:"Nanosciences";}
fonction:
Full Professor (PR1)
localisation:
Office: C418A
texte_onglets:
[tabs] [tab title=Career] Until 2007: The originality of the approach I have undertaken to synthesize and study nanomaterials was to jointly control the morphology, the size distribution, the nature of the interfaces and the stoichiometry of the products. Indeed, many controversies in literature come from the non-control of one of these parameters (evolution of the lattice parameters, phase transition temperatures...). Some of these controversies have thus been excluded thanks to the approach I have developed. After 2007 (after my habilitation): I refocused my work to initiate, in my laboratory, a new thematic about bioapplications of nanopowders. Head of Resarch Team (Bio-)hybrid nanoparticles & nanostructures BH2N The key nanomaterials studied are:
  • SPIONs (SuperParamagnetic Iron Oxide Nanoparticles) for multimodal imaging (MRI/PET and MRI/optical imaging). Two strengths are put to use (i) the originality of their simultaneous synthesis and colloidal stabilization in one step through a hydrothermal synthesis device working continuously (synthesis time <10 s, conditions T, P up to the supercritical water field) and (ii) the association of these nanoparticles with innovative chelating agents (NODAGA, MANOTA etc.) or innovative fluorophores (phtalocyanine in particular).
  • Titanate nanotubes (TiONts) that few teams in the world are able to synthesize. For the first time, these nanoparticles are developed for applications related to their ability to be internalized in various cell types. They have proven themselves for DNA transfection and radiosensitizing of tumors (glioblastoma and prostate cancer).
> Curriculum Vitae (English) [/tab] [tab title=Projects]
  • Principal investigator of a scientific project supported by joint funds through the CNRS/Burgundy Council/University of Burgundy trilateral agreement: 3MIM ("Marquage de Molécules par les Métaux pour l’Imagerie Médicale", in English "Labelling of Molecules with Metals for Medical Imaging"), Project: "Multifonctionnal nanomaterials for biomedical applications": This project involves collaborative efforts from 19 researchers spread over three laboratories of the University of Burgundy (ICB, ICMUB, LE2I), two hospitals (CHU de Dijon and CGFL) and a biotechnology company (NVH Medicinal)
  • Principal investigator and founder of "Bourgogne-Nanocare" platform, Satt Grand Est (Welience), in collaboration with INSERM U866: development of cytotoxicity assays, genotoxicity assays, DCFDA cellular ROS detection assays, ecotoxicity assays (Zebrafish), biodistribution studies (MRI, PET, SPECT, OI) to evaluate nanoparticle toxicity or safety profile
> Nanocare platform
  • Principal investigator of a thematic in the Equipex IMAPPI (Integrated Magnetic resonance And Positron emission tomography in Preclinical Imaging) funded by the General Commission for Investment and the French Government- One scientific project in progress for the development of bimodal contrast agents based on SPIONs (MRI/PET)
> Equipex IMAPPI
  • Principal investigator of two projects with the radiotherapy department of the French Comprehensive Cancer Center "Titanate nanotubes as new nanovectors of radiosensitizers: internalization, radiosensitizing and biodistribution of these nanohybrids, vectors of docetaxel, in case of prostate cancers in nude mouse model " (co-principal investigator Prof. G. Créhange). Project funded by the Cancer League "Grand-Est" (2012/2013) "Nanohybrids based on titanate nanotubes and gold nanoparticles as new radiosensitizers of prostate cancer". Project funded by the Greater East Cancer Research Clusters (2015/2017)
  • Principal investigator of an agreement with the biotechnology company NVH Medicinal (signed in 2010 for 4 years and renewed in 2015). Scientific topic: nanoparticles, proteins and regenerative medicine
> NVH Medical
  • Principal investigator of a scientific theme inside PARI2 Nano2Bio (2014/2020): "Nanoparticles for the vectorization of drugs and for regenerative medicine"
[/tab] [tab title=Presentations] 195 communications:
  • 28 invited conferences (14 in international congresses)
  • 13 invited seminars (5 abroad)
  • 13 popular science lectures (with personal invitation)
Awards:
  • European Ceramic Society award (Brighton, UK), 1998
  • French Ceramic Society award (Paris, France), 1998
  • JECH award (Paris, France, Heterogeneous Kinetic), 1998
Principal investigator and founder of the national training action ANF NanoMed 2018 Member of the scientific committee of ICONAN 2016, 2017 and 2018 Some upcoming or recent communications:
  • Biomedical applications of nanoparticles: new nanoplatforms for theranostic. Some examples in oncology, cardiovascular diseases, gene therapy and neurosciences, N. Millot, "IV Congreso Internacional de Salud Integral, IX Congreso Francés de Ciencias y Tecnologías Avanzadas, I Congreso Internacional de l'APSP”, 27-29 October 2016, Santa Marta (Colombia), Invited Conference
  • Innovative SPIONs for multimodal imaging: MRI/PET and MRI/optical imaging, J. Boudon, G. Thomas, J. Paris, L. Maurizi, N. Millot, ICONAN 2016, 28-30 September 2016, Paris (France)
  • Preclinical development of a titanate-docetaxel nanohybrid for the treatment of prostate cancer, J. Boudon, C. Mirjolet, A. Loiseau, G. Créhange, N. Millot, MRS Fall Meeting, 29 novembre-4 December 2015, Boston (USA)
  • DOTA-Functionalized Magnetite Nanoparticles as Contrast Agents for MRI/PET Double Imaging, G. Thomas, F. Demoisson, J. Boudon, J. Paris, N. Millot, Nano 2014, 13-18 Jully 2014, Moscou (Russia), Invited Conference
  • Development of novel versatile theranostic platforms: from SPIONs to titanate nanotubes, N. Millot, 4th Zing Bionanomaterials Conference, 6-9 April 2014, Narja (Spain), Invited Conference
[/tab] [tab title=Publications] [iframe src="/publications/membres/MILLOT_Nadine.html" width="100%" height="500"] Researcher unique identifiers:
  • Google Scholar : 0000-0002-0127-3858 (ORCID ID)
  • Researcher ID : M-5589-2016
  • SCOPUS ID : 55919080100
> Special Issue "Biomedical Applications of Nanoparticles"
  • 1 international patent "Titanate nanostructures for regenerative medicine and tissue engineering", WO 2014/079890 A1 Millot Nadine, Vandroux David, Bellat Vanessa
  • 12 conference proceedings (two of them referenced by Sci. Finder Scholar)
  • 2 book chapters: Nanomedicine (One Central Press, UK 2014) "Titanate nanotubes as a versatile platform for nanomedicine" J. Boudon, A.L. Papa, J. Paris, N. Millot
Unraveling the Safety Profile of Nanoscale Particles and Materials - From Biomedical to Environmental Applications
  • "Toxicological risk assessment of emerging nanomaterials: cytotoxicity, cellular uptake, effects on biogenesis and cell organelle activity, acute toxicity and biodistribution of oxide nanoparticles" L. Maurizi, A.L. Papa, J. Boudon, S. Sruthi, B. Pruvot, D. Vandroux, J. Chluba, G. Lizard, N. Millot, Chapter 2, Edited by Andreia C. Gomes and Marisa P. Sarria, InTech - open science, 2018 ISBN 978-953-51-3940-9, Published: March 21, 2018
  • 1 popular article: "Nanoparticules : de nouveaux outils thérapeutiques déjà éprouvés. Danger ou formidable espoir pour la société ?" N. Millot, Réalités Pédiatriques – n° 207_Janvier 2017
Relevant publications of the last years:
  • "Taxane-grafted metal-oxide nanoparticles as a new theranostic tool against cancer: the promising example of docetaxel-functionalized titanate nanotubes in preclinical development on prostate tumors", A. Loiseau, J. Boudon, C. Mirjolet, G. Créhange, N. Millot, Adv. Healthcare Mater. 1700245 (2017)
  • "One-step continuous synthesis of functionalized magnetite nanoflowers", G. Thomas, F. Demoisson, R. Chassagnon, E. Popova, N. Millot, Nanotechnology 27, 135604-135619 (2016)
  • "Influence of surface charge and polymer coating on internalization and biodistribution of PEG-modified iron oxide nanoparticles", L. Maurizi, A.L. Papa, L. Dumont, F. Bouyer, D. Vandroux, P. Walker, N. Millot, J. Biomed. Nanotechnol. 11, 126–136 (2015)
  • "Titanate nanotubes: towards a novel and safer nanovector for cardiomyocytes", A.L. Papa, L. Dumont, D. Vandroux, N. Millot, Nanotoxicology 7 (6), 1131 (2013)
  • "The radiosensitization effect of titanate nanotubes as a new tool in radiation therapy for glioblastoma: a proof-of-concept", C. Mirjolet, A.L. Papa, G. Créhanges, G. Truc, P. Maingon, N. Millot, Radioth. Oncol. 108, 136 (2013)
[/tab] [tab title=Lectures] Principal advisor of International Relations of ESIREM, Materials Department Principal advisor of ESIREM internships, Materials Department (for the past 12 years) Control of the placement of 45 students each year, co-writing of a quality charter on internships, advice for students, personal placement of 5 to 10 students each year, administrative follow-up of internships, choice of the tutors at the university, organization of the oral defenses. Teaching duties 2015/2016 : 
  • ESIREM 3rd year, "Cristallography", Lecture (15 h), Tutorial (24 h)
  • ESIREM 4th and 5th years, "Responsibility of internships" (34 h)
  • ESIREM 4th and 5th years, "Ceramic", Tutorial (6 h), Practical Work (56 h)
  • BSc in Chemistry (Licence 3), "Nanopowders", Lecture (18 h), Practical Work (21 h)
  • Master 2 Nanosciences and Master 2 CDM (Control and Durability of Materials) "The impact of nanomaterials on Health and Safety", Lecture (12 h) "Nanohybrids: Biomedical Applications", Lecture (6 h)
Author of an educational book, Lavoisier Editions (Paris, February 2014) "Cristallographie Géométrique - Cours - Exercices et Problèmes corrigés" (266 pages), Nadine MILLOT, Jean-Claude NIEPCE, Graduate-level, Engineering school [/tab] [tab title=Administration]
  • Member of the steering committee of the C'Nano Grand-Est (since 2018)
  • Member of the steering committee of the C'Nano France (since 2018)
  • Selection Committee Chair for Chemistry of the University of Burgundy 31/32/33 sections
  • Member of the scientific committee of the GIS Pharmaco-Imagery (since its creation in 2016)
  • Member of the BFCare cluster (since 2008)
  • Elected member of CNU, section 31 (alternate) (in 2015-2016)
  • Expert of the ANR agency, of the F.R.S.-FNRS (Belgium) and of several universities
[/tab] [/tabs]
carriere:
Until 2007: The originality of the approach I have undertaken to synthesize and study nanomaterials was to jointly control the morphology, the size distribution, the nature of the interfaces and the stoichiometry of the products. Indeed, many controversies in literature come from the non-control of one of these parameters (evolution of the lattice parameters, phase transition temperatures...). Some of these controversies have thus been excluded thanks to the approach I have developed. After 2007 (after my habilitation): I refocused my work to initiate, in my laboratory, a new thematic about bioapplications of nanopowders. Head of Resarch Team (Bio-)hybrid nanoparticles & nanostructures BH2N The key nanomaterials studied are:
  • SPIONs (SuperParamagnetic Iron Oxide Nanoparticles) for multimodal imaging (MRI/PET and MRI/optical imaging). Two strengths are put to use (i) the originality of their simultaneous synthesis and colloidal stabilization in one step through a hydrothermal synthesis device working continuously (synthesis time <10 s, conditions T, P up to the supercritical water field) and (ii) the association of these nanoparticles with innovative chelating agents (NODAGA, MANOTA etc.) or innovative fluorophores (phtalocyanine in particular).
  • Titanate nanotubes (TiONts) that few teams in the world are able to synthesize. For the first time, these nanoparticles are developed for applications related to their ability to be internalized in various cell types. They have proven themselves for DNA transfection and radiosensitizing of tumors (glioblastoma and prostate cancer).
> Curriculum Vitae (English)
projets:
  • Principal investigator of a scientific project supported by joint funds through the CNRS/Burgundy Council/University of Burgundy trilateral agreement: 3MIM ("Marquage de Molécules par les Métaux pour l’Imagerie Médicale", in English "Labelling of Molecules with Metals for Medical Imaging"), Project: "Multifonctionnal nanomaterials for biomedical applications": This project involves collaborative efforts from 19 researchers spread over three laboratories of the University of Burgundy (ICB, ICMUB, LE2I), two hospitals (CHU de Dijon and CGFL) and a biotechnology company (NVH Medicinal)
  • Principal investigator and founder of "Bourgogne-Nanocare" platform, Satt Grand Est (Welience), in collaboration with INSERM U866: development of cytotoxicity assays, genotoxicity assays, DCFDA cellular ROS detection assays, ecotoxicity assays (Zebrafish), biodistribution studies (MRI, PET, SPECT, OI) to evaluate nanoparticle toxicity or safety profile

> Nanocare platform

  • Principal investigator of a thematic in the Equipex IMAPPI (Integrated Magnetic resonance And Positron emission tomography in Preclinical Imaging) funded by the General Commission for Investment and the French Government- One scientific project in progress for the development of bimodal contrast agents based on SPIONs (MRI/PET)

> Equipex IMAPPI

  • Principal investigator of two projects with the radiotherapy department of the French Comprehensive Cancer Center "Titanate nanotubes as new nanovectors of radiosensitizers: internalization, radiosensitizing and biodistribution of these nanohybrids, vectors of docetaxel, in case of prostate cancers in nude mouse model " (co-principal investigator Prof. G. Créhange). Project funded by the Cancer League "Grand-Est" (2012/2013) "Nanohybrids based on titanate nanotubes and gold nanoparticles as new radiosensitizers of prostate cancer". Project funded by the Greater East Cancer Research Clusters (2015/2017)
  • Principal investigator of an agreement with the biotechnology company NVH Medicinal (signed in 2010 for 4 years and renewed in 2015). Scientific topic: nanoparticles, proteins and regenerative medicine

> NVH Medical

  • Principal investigator of a scientific theme inside PARI2 Nano2Bio (2014/2020): "Nanoparticles for the vectorization of drugs and for regenerative medicine"
communications:
195 communications:
  • 28 invited conferences (14 in international congresses)
  • 13 invited seminars (5 abroad)
  • 13 popular science lectures (with personal invitation)
Awards:
  • European Ceramic Society award (Brighton, UK), 1998
  • French Ceramic Society award (Paris, France), 1998
  • JECH award (Paris, France, Heterogeneous Kinetic), 1998
Principal investigator and founder of the national training action ANF NanoMed 2018 Member of the scientific committee of ICONAN 2016, 2017 and 2018 Some upcoming or recent communications:
  • Development of novel versatile theranostic platforms: from SPIONs to titanate nanotubes and tantalum oxides, J. Boudon, L. Maurizi, F. Sallem, N. Millot*, SFNano, Montpellier (France), 3-5 décembre 2018
  • Continuous and reproducible functionalized nanoparticles as MRI-PET contrast agents: towards targeting multimodal probes? G. Thomas, J. Boudon, L. Maurizi, M. Moreau, P. Walker, A. Oudot, F. Demoisson, F. Denat, F. Brunotte, N. Millot*, BioNanomed 2016, 20-22 mars 2017, Krems (Austria)
  • Development of titanate nanotubes to vectorize docetaxel or combined with Au nanoparticles for the treatment of prostate cancer, A. Loiseau, J. Boudon, C. Mirjolet, G. Créhange, B. Collin, A. Oudot, S. Roux, N. Millot*, EMRS, 2-5 mai 2016, Lille (France)
  • Biomedical applications of nanoparticles: new nanoplatforms for theranostic. Some examples in oncology, cardiovascular diseases, gene therapy and neurosciences, N. Millot, "IV Congreso Internacional de Salud Integral, IX Congreso Francés de Ciencias y Tecnologías Avanzadas, I Congreso Internacional de l'APSP”, 27-29 October 2016, Santa Marta (Colombia), Invited Conference
  • Innovative SPIONs for multimodal imaging: MRI/PET and MRI/optical imaging, J. Boudon, G. Thomas, J. Paris, L. Maurizi, N. Millot*, ICONAN 2016, 28-30 September 2016, Paris (France)
  • Preclinical development of a titanate-docetaxel nanohybrid for the treatment of prostate cancer, J. Boudon, C. Mirjolet, A. Loiseau, G. Créhange, N. Millot*, MRS Fall Meeting, 29 novembre-4 December 2015, Boston (USA)
publications:
Accepted publication: Journal of Nanoscience and Nanotechnology (2019)
  • Publications extracted from Web of Science:
[iframe src="/publications/membres/MILLOT_Nadine.html" width="100%" height="500"]
  • Researcher unique identifiers:

Google Scholar

ORCID

Researcher ID

Scopus

  • Guest Editor of a Special issue of Nanomaterials (19 papers published)

> Special Issue "Biomedical Applications of Nanoparticles"

  • 1 international patent "Titanate nanostructures for regenerative medicine and tissue engineering", WO 2014/079890 A1 Millot Nadine, Vandroux David, Bellat Vanessa
  • 12 conference proceedings (two of them referenced by Sci. Finder Scholar)
  • 2 book chapters: * Nanomedicine (One Central Press, UK 2014) "Titanate nanotubes as a versatile platform for nanomedicine" J. Boudon, A.L. Papa, J. Paris, N. Millot* Unraveling the Safety Profile of Nanoscale Particles and Materials - From Biomedical to Environmental Applications, Edited by Andreia C. Gomes and Marisa P. Sarria, InTech - open science, 2018 ISBN 978-953-51-3940-9, Published: March 21, 2018 "Toxicological risk assessment of emerging nanomaterials: cytotoxicity, cellular uptake, effects on biogenesis and cell organelle activity, acute toxicity and biodistribution of oxide nanoparticles" L. Maurizi, A.L. Papa, J. Boudon, S. Sruthi, B. Pruvot, D. Vandroux, J. Chluba, G. Lizard, N. Millot, Chapter 2,
  • 1 popular article: "Nanoparticules : de nouveaux outils thérapeutiques déjà éprouvés. Danger ou formidable espoir pour la société ?" N. Millot, Réalités Pédiatriques – n° 207_Janvier 2017
Relevant publications of the last years:
  • "Taxane-grafted metal-oxide nanoparticles as a new theranostic tool against cancer: the promising example of docetaxel-functionalized titanate nanotubes in preclinical development on prostate tumors", A. Loiseau, J. Boudon, C. Mirjolet, G. Créhange, N. Millot, Adv. Healthcare Mater. 1700245 (2017)
  • "One-step continuous synthesis of functionalized magnetite nanoflowers", G. Thomas, F. Demoisson, R. Chassagnon, E. Popova, N. Millot, Nanotechnology 27, 135604-135619 (2016)
  • "Influence of surface charge and polymer coating on internalization and biodistribution of PEG-modified iron oxide nanoparticles", L. Maurizi, A.L. Papa, L. Dumont, F. Bouyer, D. Vandroux, P. Walker, N. Millot, J. Biomed. Nanotechnol. 11, 126–136 (2015)
  • "Titanate nanotubes: towards a novel and safer nanovector for cardiomyocytes", A.L. Papa, L. Dumont, D. Vandroux, N. Millot, Nanotoxicology 7 (6), 1131 (2013)
  • "The radiosensitization effect of titanate nanotubes as a new tool in radiation therapy for glioblastoma: a proof-of-concept", C. Mirjolet, A.L. Papa, G. Créhanges, G. Truc, P. Maingon, N. Millot, Radioth. Oncol. 108, 136 (2013)
enseignements:
Principal advisor of International Relations of ESIREM, Materials Department Principal advisor of ESIREM internships, Materials Department (for the past 12 years) Control of the placement of 45 students each year, co-writing of a quality charter on internships, advice for students, personal placement of 5 to 10 students each year, administrative follow-up of internships, choice of the tutors at the university, organization of the oral defenses. Teaching duties 2015/2016 : 
  • ESIREM 3rd year, "Cristallography", Lecture (15 h), Tutorial (24 h)
  • ESIREM 4th and 5th years, "Responsibility of internships" (34 h)
  • ESIREM 4th and 5th years, "Ceramic", Tutorial (6 h), Practical Work (56 h)
  • BSc in Chemistry (Licence 3), "Nanopowders", Lecture (18 h), Practical Work (21 h)
  • Master 2 Nanosciences and Master 2 CDM (Control and Durability of Materials) "The impact of nanomaterials on Health and Safety", Lecture (12 h) "Nanohybrids: Biomedical Applications", Lecture (6 h)
Author of an educational book, Lavoisier Editions (Paris, February 2014) "Cristallographie Géométrique - Cours - Exercices et Problèmes corrigés" (266 pages), Nadine MILLOT, Jean-Claude NIEPCE, Graduate-level, Engineering school
administration:
  • Member of the steering committee of the C'Nano Grand-Est (since 2018)
  • Member of the steering committee of the C'Nano France (since 2018)
  • Selection Committee Chair for Chemistry of the University of Burgundy 31/32/33 sections
  • Member of the scientific committee of the GIS Pharmaco-Imagery (since its creation in 2016)
  • Member of the BFCare cluster (since 2008)
  • Elected member of CNU, section 31 (alternate) (in 2015-2016)
  • Expert of the ANR agency, of the F.R.S.-FNRS (Belgium) and of several universities
kc_data:
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