(Bio-)Hybrid Nanoparticles & Nanostructures

(Bio-)Hybrid Nanoparticles & Nanostructures (BH2N) is a group of the Nanosciences department from the laboratory ICB. It is lead by Julien Boudon and includes different activities.

Julien BOUDON

Group head

julien.boudon[at]u-bourgogne.fr
Tél : +333 80 39 59 42

Iron Oxide Nanoparticles (SPIONs) for multimodal imaging

SPIONs-phtalocyanine (Pc) nanohybrids developed as bimodal contrast agents for optical imaging (OI) and magnetic resonance imaging (MRI)
SPIONs Nanohybrids surface modification by 3,4-dihydroxy-L-phenylalanine (LDOPA) or 3,4-dihydroxyhydrocinnamic acid (DHCA)
SPIONs-LDOPA-PEG2000-MANOTA[64Cu] Nanohybrids evaluated in vitro and in vivo by MRI-PET
Protein grafting at the surface of bimodal SPIONs to target cardiovascular diseases and monitor them by MRI-PET (cardiotoxicity induced by chemotherapy)
Combination of TiONts + AuNPs to optimize the nanoplatform dedicated to the radiosensibilization of prostate cancer
Neurodegenerative diseases: peroxisomal and mitochondrial targeting with multifunctional SPIONs

Contacts: L. Maurizi, J. Boudon, N. Millot

Therapeutic nanocarriers made from titanate nanotubes

TiONts-SPIONs: MRI-detectable nanocarriers
TiONts-phthalocyanine (Pc): promising optical imaging (OI)-detectable nanocarriers
TiONts-docetaxel (DTX): concentration of a radiosensitzing nanocarrier into tumors
TiONts-DOTA: nanohybrids biodistribution by SPECT-CT nuclear imaging

Related information: J. Phys. Chem. C 2011, RSC. Adv. 2015, Nanomedicine Ed. One Central Press 2014, Radiother. Oncol. 2013, Eur. J. Cancer 2014

Contacts: J. Boudon, N. Millot

Titanate nanoribbons (TiONrs) for regenerative medicine

Controlled synthesis, reproducible and 99% pure
TiONrs functionalization by polyethylene glycol (PEG) to graft proteins
Lysine coupling: cellular adhesion

Related information: Dalton Trans. 2015, Brevet 2014 WO 2014/079890

Contacts: V. Bérard, N. Millot

Acoustic vibrations of nano-objects

role of size, shape, crystalline structure and environment
continuum elasticity, symmetry of the vibrations
Raman scattering, light-vibration coupling

Related information: Phys. Rev. B 2018, ACS Nano 2020

Contact: L. Saviot

Tantalum oxide nanoparticles (TaONPs)

Development of novel tantalum oxide nanoparticles (TaONPs) as a theranostic platform
Functionalization of TaONPs surface for the grafting of molecules of interest
Grafting of anticancer molecules
Tomodensitometry

Contacts: J. Boudon, N. Millot

Nanoparticle toxicity and security evaluation

Cytotoxicity assays (MTT, Alamar blue, kinetics of RNA synthesis)
Genotoxicity assays (comet assay, Ames assay, micronucleus assays)
Carcinogenicity assays (cell transformation assay)
Study, understanding and control of nanomaterial-protein interactions

Contacts: L. Maurizi, N. Millot

BH2N publications

Means & applications

The group has different elaboration and characterization techniques dedicated to the engineered nanoparticles and nanostructures.

Elaboration

Characterization

Applications

Medical imaging: magnetic (MRI), nuclear (SPECT, PET)
Therapy: anticancer nanodrugs, tumor radiosensibilization, photodynamic therapy

Team members

Permanent members

Véronique BERARD, AP
Julien BOUDON, AP
Coralie FEVRE, Administrative & Financial Manager
Michaële HERBST, AE
Lionel MAURIZI, R
Nadine MILLOT, FP
Raminfar Al RAFRAFIN, T (50%)
Lucien SAVIOT, SR

Non-permanent members

Margaux DESSEIGNE, post-doctorante
Eduardo HERNANDO ABAD, PhD student
Amira MAHMOUD, PhD student
Célia MARETS, PhD student
Mélanie ROMAIN, PhD student

Associated collaborators

Nicole ABOU HAMAD, PhD student (Agrosup)
Damien GOULLEY, PhD student (Pharma)
Alan ZERROUKI, PhD student (Interface/PMDM)

Scientific guests

	BH2N team has welcome Dr. Mitsunori YADA (Saga University, Japan) Department of Chemistry and Applied Chemistry from May 27 to August 26 2019 Details: Dpt. Chem. Univ. Saga’s website

	BH2N team has welcome Prof. Dr. Gerold Schneider(Technische Universität Hamburg, Germany) Head of Institute of Advanced Ceramics From June 18th to July 13th 2018 Details: Institute Advanced Ceramics’ website

	BH2N team has welcome Dr. Katrin Löschner(Technical University of Denmark, Denmark)National Food Institute Research Group for Nano-Bio Science From 3rd to May 29th 2018 More details:K. Löschner’s webpage

Former members

Daniel AYMES (Associate Professor)
Vanessa BELLAT (PhD student)
Frédéric BOUYER (Assistant Professor)
Laroussi CHAABANE, Postdoctoral fellow (Agrosup)
Thomas COURANT (Postdoctoral fellow, 2014-2015)
Florent CREVAT (PhD student, 2013-2017)
Moustafa EL KASS (Postdoctoral teaching and research assistant, 2014-2015)
Jordan GUICHARD (PhD student CEA Valduc, 2012-2015)
Sullivan GUY (Master’s student, 2021)
Aicha HAMIDI (Master’s student, 2022)
Gautier LAURENT (Postdoctoral fellow, 2016-2017)
Alexis LOISEAU (PhD student, 2014-2017)
Annette LUCE (PhD student 2016-2020)
Renée MAYAP TALOM (Postdoctoral fellow)
Léa PAGEARD (Master’s student, 2021)
Anne-Laure PAPA (PhD student)
Jérémy PARIS (PhD student)
Roy ROUKOS (PhD student)
Yasmine SAIBI (Research engineer)
Fadoua SALLEM (PhD student then Post-doctal fellow)
Fariza SI AHMED (PhD student, 2013-2016)
Mohammad SIDDIQUI (Master’s student, 2022)
Nimisha SINGH (PhD student, Raman-Charpak fellowship 2017-2018, Postdoctoral fellow, 2020-2021)
Sruthi SUDHAKARAN (PhD student, Raman-Charpak fellowship 2015-2016)
Guillaume THOMAS (PhD student, 2012-2015)
Mathieu VARACHE (PhD student)

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(Bio-)Hybrid Nanoparticles & Nanostructures

(Bio-)Hybrid Nanoparticles & Nanostructures (BH2N) is a group of the Nanosciences department from the laboratory ICB. It is lead by Julien Boudon and includes different activities.

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Julien BOUDON

Group head

julien.boudon[at]u-bourgogne.fr
Tél : +333 80 39 59 42

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PhD offer
Starting early October 2020Are you Interested in starting a PhD on the "Synthesis of hybrid nanoparticles targeting extracellular vesicles"? Apply the offer by clicking the image on the left (pdf file, 221 Ko).

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{slide=Iron Oxide Nanoparticles (SPIONs) for multimodal imaging}

SPIONs-phtalocyanine (Pc) nanohybrids developed as bimodal contrast agents for optical imaging (OI) and magnetic resonance imaging (MRI)
SPIONs Nanohybrids surface modification by 3,4-dihydroxy-L-phenylalanine (LDOPA) or 3,4-dihydroxyhydrocinnamic acid (DHCA)
SPIONs-LDOPA-PEG2000-MANOTA[64Cu] Nanohybrids evaluated in vitro and in vivo by MRI-PET
Protein grafting at the surface of bimodal SPIONs to target cardiovascular diseases and monitor them by MRI-PET (cardiotoxicity induced by chemotherapy)
Combination of TiONts + AuNPs to optimize the nanoplatform dedicated to the radiosensibilization of prostate cancer
Neurodegenerative diseases: peroxisomal and mitochondrial targeting with multifunctional SPIONs

Contacts: L. Maurizi, J. Boudon, N. Millot

{/slide}

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{slide=Therapeutic nanocarriers made from titanate nanotubes}

TiONts-SPIONs: MRI-detectable nanocarriers
TiONts-phthalocyanine (Pc): promising optical imaging (OI)-detectable nanocarriers
TiONts-docetaxel (DTX): concentration of a radiosensitzing nanocarrier into tumors
TiONts-DOTA: nanohybrids biodistribution by SPECT-CT nuclear imaging

Related information: J. Phys. Chem. C 2011, RSC. Adv. 2015, Nanomedicine Ed. One Central Press 2014, Radiother. Oncol. 2013, Eur. J. Cancer 2014

Contacts: J. Boudon, N. Millot

{/slide}

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{slide=Titanate nanoribbons (TiONrs) for regenerative medicine}

Controlled synthesis, reproducible and 99% pure
TiONrs functionalization by polyethylene glycol (PEG) to graft proteins
Lysine coupling: cellular adhesion

Related information: Dalton Trans. 2015, Brevet 2014 WO 2014/079890

Contacts: V. Bérard, N. Millot

{/slide}

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{slide=Elaboration of mesoporous silica nanoparticles (MSNs) for a controlled delivery of anticancer drugs}

High yield synthesis of dispersed MSNs
Improvement of the structural stability of MSNs
Study of the influence of surface chemistry on the dispersion of MSNs and the encapsulation of drugs
Study of the influence of surface chemistry on MSNs cytotoxicity (preliminary data)
Development of MSNs-gold nanoparticles (AuNPs) nanohybrids or (AuNPs) for pH-sensitive drug delivery (by pH-cleavable bonds)
in vitro and in vivo evaluation of the best formulations of MSNs

Related information: J. Non-Cryst. Solids 2015, J. Nanopart. Res. 2015

Contact: F. Bouyer

{/slide}

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{slide=Titanate nanoribbons (TiONrs) for regenerative medicine}

Controlled synthesis, reproducible and 99% pure
TiONrs functionalization by polyethylene glycol (PEG) to graft proteins
Lysine coupling: cellular adhesion

Related information: Dalton Trans. 2015, Brevet 2014 WO 2014/079890

Contacts: V. Bérard, N. Millot

{/slide}

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{slide=Acoustic vibrations of nano-objects}

role of size, shape, crystalline structure and environment
continuum elasticity, symmetry of the vibrations
Raman scattering, light-vibration coupling

Related information: Phys. Rev. B 2018, ACS Nano 2020

Contact: L. Saviot

{/slide}

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{slide=Tantalum oxide nanoparticles (TaONPs)}

Development of novel tantalum oxide nanoparticles (TaONPs) as a theranostic platform
Functionalization of TaONPs surface for the grafting of molecules of interest
Grafting of anticancer molecules
Tomodensitometry

Contacts: J. Boudon, N. Millot

{/slide}

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{slide=Nanoparticle toxicity and security evaluation}

Cytotoxicity assays (MTT, Alamar blue, kinetics of RNA synthesis)
Genotoxicity assays (comet assay, Ames assay, micronucleus assays)
Carcinogenicity assays (cell transformation assay)
Study, understanding and control of nanomaterial-protein interactions

Contacts: L. Maurizi, N. Millot

{/slide}

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{slide=TiO2 growth by MOCVD and study of growth mechanisms}

Random LASERs
Understanding of the catalyzed growth of doped TiO2 nanostructures

Related information: Optics Express 2012

Contact: D. Chaumont

{/slide}

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{slide=Tantalum oxide nanoparticles (TaONPs)}

Development of novel tantalum oxide nanoparticles (TaONPs) as a theranostic platform
Functionalization of TaONPs surface for the grafting of molecules of interest
Grafting of anticancer molecules
Tomodensitometry

Contacts: J. Boudon, N. Millot

{/slide}

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{slide=BH2N publications}

[iframe src="/publications/groupes/NANO1.html"width="100%" height="500"]

{/slide}

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{slide=BH2N publications}

[iframe src="/publications/groupes/NANO1.html"width="100%" height="500"]

{/slide}

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Means & applications

The group has different elaboration and characterization techniques dedicated to the engineered nanoparticles and nanostructures.

[/kc_column_text][kc_spacing height="20" _id="796416"][kc_column_text _id="362156"]

Elaboration

[/kc_column_text][kc_spacing height="20" _id="203646"][kc_carousel_images img_size="full" items_number="3" tablet="2" mobile="1" speed="100" pagination="__empty__" auto_play="__empty__" alt_text="yes" _id="273999" images="11865,11860,11861,11868" onclick="lightbox" navigation="yes" nav_style="arrow" auto_height="yes"][kc_spacing height="20" _id="564248"][kc_column_text _id="48890"]

Characterization

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Applications

[/kc_column_text][kc_column_text _id="62846"]

Medical imaging: magnetic (MRI), nuclear (SPECT, PET)
Therapy: anticancer nanodrugs, tumor radiosensibilization, photodynamic therapy

[/kc_column_text][/kc_column][kc_column width="10%" _id="104265"][/kc_column][kc_column width="34%" _id="254683"][kc_column_text _id="691235"]

Team members

[/kc_column_text][kc_spacing height="20" _id="574226"][kc_column_text _id="139568"]

{slide=Permanent members}

Véronique BERARD, AP
Julien BOUDON, AP
Coralie FEVRE, Administrative & Financial Manager
Michaële HERBST, AE
Lionel MAURIZI, R
Nadine MILLOT, FP
Raminfar Al RAFRAFIN, T (50%)
Lucien SAVIOT, SR

{/slide}

[/kc_column_text][kc_spacing height="20" _id="200870"][kc_column_text _id="600406"]

{slide=Non-permanent members}

Margaux DESSEIGNE, post-doctorante
Eduardo HERNANDO ABAD, PhD student
Amira MAHMOUD, PhD student
Célia MARETS, PhD student
Mélanie ROMAIN, PhD student

Associated collaborators

Nicole ABOU HAMAD, PhD student (Agrosup)
Damien GOULLEY, PhD student (Pharma)
Alan ZERROUKI, PhD student (Interface/PMDM)

{/slide}

[/kc_column_text][kc_spacing height="20" _id="374724"][kc_column_text _id="539154"]

{slide=Scientific guests}

	BH2N team has welcome Dr. Mitsunori YADA (Saga University, Japan) Department of Chemistry and Applied Chemistry from May 27 to August 26 2019 Details: Dpt. Chem. Univ. Saga's website

	BH2N team has welcome Prof. Dr. Gerold Schneider(Technische Universität Hamburg, Germany) Head of Institute of Advanced Ceramics From June 18th to July 13th 2018 Details: Institute Advanced Ceramics' website

	BH2N team has welcome Dr. Katrin Löschner(Technical University of Denmark, Denmark)National Food Institute Research Group for Nano-Bio Science From 3rd to May 29th 2018 More details:K. Löschner's webpage

{/slide}

[/kc_column_text][kc_spacing height="20" _id="784791"][kc_column_text _id="444595"]

{slide=Former members}

Daniel AYMES (Associate Professor)
Vanessa BELLAT (PhD student)
Frédéric BOUYER (Assistant Professor)
Laroussi CHAABANE, Postdoctoral fellow (Agrosup)
Thomas COURANT (Postdoctoral fellow, 2014-2015)
Florent CREVAT (PhD student, 2013-2017)
Moustafa EL KASS (Postdoctoral teaching and research assistant, 2014-2015)
Jordan GUICHARD (PhD student CEA Valduc, 2012-2015)
Sullivan GUY (Master's student, 2021)
Aicha HAMIDI (Master's student, 2022)
Gautier LAURENT (Postdoctoral fellow, 2016-2017)
Alexis LOISEAU (PhD student, 2014-2017)
Annette LUCE (PhD student 2016-2020)
Renée MAYAP TALOM (Postdoctoral fellow)
Léa PAGEARD (Master's student, 2021)
Anne-Laure PAPA (PhD student)
Jérémy PARIS (PhD student)
Roy ROUKOS (PhD student)
Yasmine SAIBI (Research engineer)
Fadoua SALLEM (PhD student then Post-doctal fellow)
Fariza SI AHMED (PhD student, 2013-2016)
Mohammad SIDDIQUI (Master's student, 2022)
Nimisha SINGH (PhD student, Raman-Charpak fellowship 2017-2018, Postdoctoral fellow, 2020-2021)
Sruthi SUDHAKARAN (PhD student, Raman-Charpak fellowship 2015-2016)
Guillaume THOMAS (PhD student, 2012-2015)
Mathieu VARACHE (PhD student)

{/slide}

[/kc_column_text][/kc_column][/kc_row]

(Bio-)Hybrid Nanoparticles & Nanostructures

Julien BOUDON

Group head

Means & applications

Elaboration

Characterization

Applications

Team members

(Bio-)Hybrid Nanoparticles & Nanostructures

Julien BOUDON

Group head

Means & applications

Elaboration

Characterization

Applications

Team members

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