C’Nano Congress: Mélanie Romain, doctoral student at the ICB wins the prize for the best oral communication
Mélanie Romain, 3rd year doctoral student in the Nanosciences department (ICB Laboratory), in collaboration with Femto-ST obtained the prize for the best oral communication of the Nanobiosciences session at the C'Nano congress which was held on 15, 16 and 17 last March in Poitiers.
- Contact : Melanie.romain@u-bourgogne.fr
Extracellular vesicles (EVs) present a growing field of interest due to their ability for biological content transport between cells thus making them promising biomakers for diagnosis or therapeutic follow-up. However it is very difficult to specifically target, isolate or characterize them because their circulation happens in complex samples (blood and other biological media). This PhD project aims to separate EVs sub-populations thanks to an acoustofluidic device that enable a first sorting based on physico-chemical properties. In order to refine sorting based on biological characteristics, targeted EVs will be modified by hybrid nanoparticles (NPs) to extract additional information and improve diagnosis. Two types of hybrid NPs, based on noble metal and magnetic oxydes, are used for this purpose, and functionnalized depending on the biomarkers of interests.
- Synthesis of hybrid Nanoparticles to target Extracellular Vesicles, Mélanie ROMAIN, Phoolan ROMAN, Daniel GUNEYSU, Wilfrid BOIREAU, Nadine MILLOT
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Mélanie Romain, 3rd year doctoral student in the Nanosciences department (ICB Laboratory), in collaboration with Femto-ST obtained the prize for the best oral communication of the Nanobiosciences session at the C'Nano congress which was held on 15, 16 and 17 last March in Poitiers.
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Extracellular vesicles (EVs) present a growing field of interest due to their ability for biological content transport between cells thus making them promising biomakers for diagnosis or therapeutic follow-up. However it is very difficult to specifically target, isolate or characterize them because their circulation happens in complex samples (blood and other biological media). This PhD project aims to separate EVs sub-populations thanks to an acoustofluidic device that enable a first sorting based on physico-chemical properties. In order to refine sorting based on biological characteristics, targeted EVs will be modified by hybrid nanoparticles (NPs) to extract additional information and improve diagnosis. Two types of hybrid NPs, based on noble metal and magnetic oxydes, are used for this purpose, and functionnalized depending on the biomarkers of interests.
Mélanie Romain- Synthesis of hybrid Nanoparticles to target Extracellular Vesicles, Mélanie ROMAIN, Phoolan ROMAN, Daniel GUNEYSU, Wilfrid BOIREAU, Nadine MILLOT
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