Fiche de : MAURIZI Lionel

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Educations and experiences

Researchgate profile

With a chemical engineering background I started in 2010 a PhD in physical-chemistry on the syntheses and characterizations of nanoparticles for biomedical applications. While going deeper into my nanoparticles skills I learned new knowledge on toxicities and biological behaviors of nanohybrids made for medical purposes.

During my postdoctoral experiences from 2011 to 2016, in particular at EPFL, I continued working on synthesis and characterizations methods "GMP-like" for nanomaterials in order to answer pharmaceutical and medical requirements. I also focused my research on the study and the understanding of the role of nanoobjects physico-chemistry on the living world especially their interactions with protein from biological media: the "Protein Corona"

This thematic is driving my actual research at ICB Laboratory (Nanosciences Department).

2007-2010: After a chemical engineering diploma from the University of Technology of Compiegne (UTC), I started a PhD in physical chemistry at the ICB Laboratory on the Elaboration of functionalized nanoparticles: applications as MRI contrast agent. My research was focused on the syntheses of magnetic nanparticles via soft chemistry or hydrothermal and continuous methods with an accurate control of the physicochemical properties and in depth characterizations. Nanoparticles' surfaces were also modified and functionalized for a better biocompatibility, less toxicity and targeting behviors in order to be used as a Magnetic Resonance Imaging (MRI) contrast agent.

2011-2015: I worked for 4 years in Pr. H. Hofmann's team at the Ecole Polytechnique Fédérale de Lausanne (EPFL) on a FP7 European project (Nanodiara) on the development of novel nanotechnology based diagnostic and therapeutic systems for arthritic diseases. My research was centered on one part on the reproducibility and scale-up of the syntheses and methods to face biomedical challenges. On another part, I studied the interactions between nanoparticles and proteins in order to better understand their biological behaviors. This scientific area is commonly called: the "Protein Corona".

2015-2016: After these projects, I continued my research at Dublin City University (Pr. Dermot Brougham) on a FP7 European project (UNION). Then at Basel University (Pr. Cornelia Palivan) I worked on a Swiss project NCCR (National Centres of Competence in Research). These two projects were focused on the development of physicochemical solutions for biomedical applications such as  "nano-flowers" or "nano-vesicles".

Since the end of 2016: I got a CNRS Researcher (CR) permanent position at the Nanosciences Department of the ICB laboratory to continue working on my thematic focused on  the development of nanomedical solutions and on the understanding of their biological behaviors.

Main fields of expertise

• Control of physico-chemistry of nanomaterials

Synthesis of inorganic nanoparticles such as iron oxide (SPIONs), titanate nanotubes (TiONTs), gold or polymeric vesicles (polymersomes). Control of the size, the oxidation state, the composition and the morphology of nanoparticles. Development of reproducible and up-scalable methods for nanomaterials.

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• "GMP-like" surface modification of nanomaterials for biomedical purposes

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Surface modification of nanoparticles for better biocompatibility (polymer, core/shell structures, organic molecules…). Functionalization of nanohybrids with targeting molecules for bimodal detections. Reproducible methods compatible with in vitro and in vivo applications especially pharmacokinetic studies.

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• Biological interactions of nanomaterials

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Studies of biological behaviors of nanoparticles such as cytotoxicity, cellular interactions and biodistribution. Development of innovative analysis methods of nanohybrids for biological studies. Understanding of the role of physico-chemistry in the interactions nanoparticles / proteins: Protein Corona.

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Main projects in progress

2022-2026: ANR JC/JC Nanoblorona
Nanoparticles in blood: understanding and controlling protein corona for optimized nanomedicine

Role during the project: Project leader.

The main goal of this project is to understand, control and optimize protein corona on NPs to avoid suffering random protein adsorption affecting the biomedical efficiencies of engineered NPs circulating in blood.

This project proposes a comprehensive study focused on NPs/proteins interactions in blood circulation in order to control their biological response.

2021-2024: ANR UFO
Up-conversion ferroelectric nanocrystal for optical sensing for electric potential in biological systems

Developing an optical nanosensor of extracellular potential in biological environment that transduces cell-related electrical changes (e.g. EAP in the case of neurons) into photoluminescence (PL) modifications relying on a mechanism never explored.

2020-2022: Collaborative Research Project France-Stanford
Monitoring therapeutic cell treatments using novel nanoprobes.
Role during the project: Project leader.

Main projects completed

2019-2022: Regional project on the studies and understanding of proteins interactions with NPs' surfaces (Inititation of a new research team ANER: Nanoprot” n° 2019-Y-10648)

Role during the project: Project leader.

2019-2020: Equipex Imappi
In vivo studies linking the interactions between proteins and nanoparticles and their biodistribution for an optimized development of nanomedicine (ANR-10-EQPX-05 IMAPPI 2020-IMAPPI-1)

Role during the project: Project leader.

2016: Swiss project NCCR (National Centers of Competence in Research)
Molecular Systems Engineering on the development of innovative molecular systems approaching the complexity of a cell.
Role during the project: Member of the project

2011-2014: FP7 European project (Nanodiara)
Development of nanotechnological tools for the detection and the therapy of arthrtic diseases.
Role during the project: Co-project leader of WP1

Summary of publications

42 articles in peer-reviewed journals

4 international conferences proceedings

4 Book chapters

Publications list and Book Chapters details

Nanoparticles in the Lung:
Environmental Exposure and Drug Delivery
Edited by Akira Tsuda and Peter Gehr

Section VI:Special Issues
Chapter 16: Physicochemical, Colloidal, and Transport Properties
(pages 251-266)

Heinrich Hofmann, Lionel Maurizi, Marie-Gabrielle Beuzelin, Usawadee Sakulkhu and Vianney Bernau

December 19, 2014 by CRC Press - 403 Pages
ISBN 9781439892794 - CAT# K14165

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Unraveling the Safety Profile of Nanoscale Particles and Materials
From Biomedical to Environmental Applications
Edited by Andreia C. Gomes and Marisa P. Sarria

Chapter 2
Toxicological Risk Assessment of Emerging Nanomaterials: Cytotoxicity, Cellular Uptake, Effects on Biogenesis and Cell Organelle Activity, Acute Toxicity and Biodistribution of Oxide Nanoparticles
(pages 17-36)

Lionel Maurizi, Anne-Laure Papa, Julien Boudon, Sruthi Sudhakaran, Benoit Pruvost, David Vandroux, Johanna Chluba, Gerard Lizard and Nadine Millot

March, 2018 by InTech - 172 Pages
ISBN 9789535139409

Computational Techniques for Analytical Chemistry and Bioanalysis
Edited by Philippe B. Wilson and Martin Grootveld

Chapter 8
Solid State Chemistry: Computational Chemical Analysis for Materials Science
(pages 287-334)

Estelina Lora da Silva, Sandra Galmarini, Lionel Maurizi, Mario Jorge Cesar dos Santos, Tao Yang, David J. Cooke and Marco Molinari

2021 by RSC - 365 Pages
ISBN 978-1-78801-461-8

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New Trends in Macromolecular and Supramolecular Chemistry for Biological Applivations
Edited by Marc J.M. Abadie, Mariane Pinteala, Alexandru Rotaru

Chapter 8
Development of Novel Versatile Theranostic Platforms Based on Titanate Nanotubes: Towards safe Nanocarriers for Biomedical Applications
(pages 151-178)

Julien Boudon, Fadoua Sallem, Alexis Loiseau, Lionel Maurizi, Anne-Laure Papa and Nadine Millot

2021 by Springer - 371 Pages
ISBN 978-3-030-57456-7

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Most significant publications

1. 1. Identification of the Proteins Determining the Blood Circulation Time of Nanoparticles, ACS Nano, 17, (13), 12458-12470, 2023 (DOI:10.1021/acsnano.3c02041)

   2. Anti-Platelet effect Induced by Iron Oxide Nanoparticles: Correlation with Conformational Change in Fibrinogen, Small, 17, (1), 2004945, 2021 (DOI:10.1002/smll.202004945)

   3. In vivo protein corona on nanoparticles: does the control of all material parameters orient the biological behavior?, Nanoscale Advances, 2021, 3, 1209-1229, 2021 (DOI: 10.1039/D0NA00863J)

   4. Beyond unpredictability: the importance of reproducibility in understanding the protein corona of nanoparticles, Bioconj. Chem., 29, (10), 3385-3393, 2018 (DOI:10.1021/acs.bioconjchem.8b00554)
   5. Significance of surface charge and shell material of Super-paramagnetic Iron Oxide Nanoparticles (SPIONs) based core/shell nanoparticles on the composition of the protein corona, Biomater. Sci., 3, (2), 265-278, 2015 (DOI:10.1039/C4BM00264D)
   6. Influence of surface charge and polymer coating on internalization and biodistribution of PEG-modified iron oxide nanoparticles, J. Biomed. Nanotech., 11, (1), 126-136, 2015 (DOI:10.1166/jbn.2015.1996)
   7. Ex situ evaluation of the composition of protein corona of intravenously injected superparamagnetic nanoparticles in rats, Nanoscale, 6, (19), 11439-11450, 2014 (DOI:10.1039/C4NR02793K)
   8. Protein Corona Composition of Superparamagnetic Iron Oxide Nanoparticles with Various Physico-Chemical Properties and Coatings, Scientific Reports, 4, 5020, 2014 (DOI:10.1038/srep05020)

Guest Editor of Special Issues

2020-2021 in Applied Sciences [IF=2.679] "Applications of nanoparticles in Pharmaceuticals"

2022-2023 in International Journal of Molecular Sciences [IF = 6.208] "Nanoparticle-Based for Diagnostics and Therapies: Interactions with Bio-Environment"

2021-2023 in Applied Sciences [IF=2.7] "Next Steps for the Production of Nanoparticles for Nanomedicine"

Communications

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56 international and national conferences including:

7 invited talks with international collaborators

Supervisions

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• 4 PhD students (2 in progress)
• 14 Master theses (1 in progress)
• ~20 students from Bachelor to Master 2 during semesters projects or short internships

Teaching

36 hours per year on supervised project: Fifth year of engineering school: ESIREM (École supérieure d'ingénieurs de recherche en matériaux et en infotronique)
5-10 hours per year of Analyses project from the Master CAC
4-8 hours per year of supervision of internship of Fourth year engineering students from ESIREM

Organizations of conferences  and general public meetings

Since 2018: Principal investigator of the event "a Class / a Researcher" where pupils meet researchers during visits of researchers to their schools and visits of pupils in the laboratory.

June 2018: Organizer of the ANF NanoMed 2018 (Summer school on Nanomedicine in 2018)