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Laboratoire Interdisciplinaire Carnot de Bourgogne



Iron Oxide Nanoparticles (SPIONs) for multimodal imaging


  • SPIONs-phtalocyanine (Pc) nanohybrids developed as bimodal contrast agents for optical imaging (OI) and magnetic resonance imaging (MRI)
  • SPIONs Nanohybrids surface modification by 3,4-dihydroxy-L-phenylalanine (LDOPA) or 3,4-dihydroxyhydrocinnamic acid (DHCA)
  • SPIONs-LDOPA-PEG2000-MANOTA[64Cu] Nanohybrids evaluated in vitro and in vivo by MRI-PET
  • Protein grafting at the surface of bimodal SPIONs to target cardiovascular diseases and monitor them by MRI-PET (cardiotoxicity induced by chemotherapy)
  • Combination of TiONts + AuNPs to optimize the nanoplatform dedicated to the radiosensibilization of prostate cancer

Related information: Chem. Commun. 2011 bouton_lien, Chem. Commun. 2013 bouton_lien, RSC. Adv. 2015 bouton_lien, J. Biomed. Nanotechnol. 2015 bouton_lien, EQUIPEX IMAPPI bouton_lien

Contacts: J. Boudon, L. Maurizi, N. Millot 


Therapeutic nanocarriers made from titanate nanotubes


  • TiONts-SPIONs: MRI-detectable nanocarriers
  • TiONts-phthalocyanine (Pc): promising optical imaging (OI)-detectable nanocarriers
  • TiONts-docetaxel (DTX): concentration of a radiosensitzing nanocarrier into tumors
  • TiONts-DOTA: nanohybrids biodistribution by SPECT-CT nuclear imaging

Related information: J. Phys. Chem. C 2011 bouton_lien, RSC. Adv. 2015 bouton_lien, Nanomedicine Ed. One Central Press 2014 bouton_lien, Radiother. Oncol. 2013 bouton_lien, Eur. J. Cancer 2014 bouton_lien

Contacts: J. Boudon, N. Millot 


Titanate nanoribbons (TiONrs) for regenerative medicine


  • Controlled synthesis, reproducible and 99% pure
  • TiONrs functionalization by polyethylene glycol (PEG) to graft proteins
  • Lysine coupling: cellular adhesion

Related information: Dalton Trans. 2015 bouton_lien, Brevet 2014 WO 2014/079890 bouton_lien

Contacts: V. Bérard, N. Millot 


Elaboration of mesoporous silica nanoparticles (MSNs) for a controlled delivery of anticancer drugs


  • High yield synthesis of dispersed MSNs
  • Improvement of the structural stability of MSNs
  • Study of the influence of surface chemistry on the dispersion of MSNs and the encapsulation of drugs
  • Study of the influence of surface chemistry on MSNs cytotoxicity (preliminary data)
  • Development of MSNs-gold nanoparticles (AuNPs) nanohybrids or (AuNPs) for pH-sensitive drug delivery (by pH-cleavable bonds)
  • in vitro and in vivo evaluation of the best formulations of MSNs

Related information: J. Non-Cryst. Solids 2015 bouton_lien, J. Nanopart. Res. 2015 bouton_lien

Contact: F. Bouyer 


TiO2 growth by MOCVD and study of growth mechanisms


  • Random LASERs
  • Understanding of the catalyzed growth of doped TiO2 nanostructures

Related information: Optics Express 2012 bouton_lien

Contact: D. Chaumont 


Tantalum oxide nanoparticles (TaONPs)


  • Development of novel tantalum oxide nanoparticles (TaONPs) as a theranostic platform
  • Functionalization of TaONPs surface for the grafting of molecules of interest
  • Grafting of anticancer molecules
  • Tomodensitometry

Contacts: J. Boudon, N. Millot 


Nanoparticle toxicity and security evaluation


  • Cytotoxicity assays (MTT, Alamar blue, kinetics of RNA synthesis)
  • Genotoxicity assays (comet assay, Ames assay, micronucleus assays)
  • Carcinogenicity assays (cell transformation assay)
  • Study, understanding and control of nanomaterial-protein interactions

Related information: Nanotoxicology 2013 bouton_lien, plateforme "NanoCare Bourgogne" bouton_lien, Nanoscale 2014 bouton_lien, Biomaterials Science 2015 bouton_lien

Contacts: L. Maurizi, N. Millot 


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Université de Bourgogne